Your Input: | |||||
TERF1 | Telomeric repeat-binding factor 1; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. (439 aa) | ||||
C2orf88 | Small membrane A-kinase anchor protein; Binds to type I regulatory subunits of protein kinase A (PKA- RI) and may anchor/target them to the plasma membrane. Belongs to the small membrane AKAP family. (95 aa) |