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STRING
STRING
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The following proteins in
Homo sapiens
appear to match your input.
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⤓ Mapping
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1) '9606.ENSP00000314153':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
2) '9606.ENSP00000377536':
PTTG1 - Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...]
[a.k.a. R-HSA-2555396, R-HSA-69278, CAG46486.1]