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TLE3 | Transducin-like enhancer protein 3; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full- length TLE family members may be modulated by association with dominant-negative AES (By similarity). (772 aa) | ||||
IL17RC | Interleukin-17 receptor C; Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA. Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA. Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1. [Isoform 6]: Does not bind IL17A or IL17F. [Isoform 8]: Receptor for both IL17A and IL17F. (791 aa) |