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PRDM11 | PR domain-containing protein 11; May be involved in transcription regulation. Belongs to the class V-like SAM-binding methyltransferase superfamily. (1177 aa) | ||||
CTDSP1 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. (261 aa) |