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The following proteins in
Homo sapiens
appear to match your input.
Please review the list, then click 'Continue' to proceed.
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⤓ Mapping
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1) 'CRX':
CRX
- Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. Belongs to the paired homeobox family.
ATXN7 - Ataxin-7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the
CRX
and is involved in
CRX
-dependent gene activation. Necessary for microtubule cytoskeleton stabilization.
[a.k.a. CCDS43102, R-HSA-5689880, NP_000324]
FIZ1 - Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress
CRX
-mediated transactivation (By similarity).
[a.k.a. BC132777, XP_005259409, 84922]
truncated ...
show all 7 options
ANKRD33 - Photoreceptor ankyrin repeat protein; Acts as a transcriptional repressor for
CRX
-activated photoreceptor gene regulation.
[a.k.a. NM_182608, 341405, AAQ07994.1]
PDC - Phosducin; May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox
CRX
. Belongs to the phosducin family.
[a.k.a. ENST00000497198, MEKA, M38059]
SAMD7 - Sterile alpha motif domain-containing protein 7; Involved in the regulation of gene expression in the retina. It functions as a negative regulator of
CRX
-controlled genes.
[a.k.a. Q7Z3H4, ENSP00000391299, NR_130713.2]
NRL - Neural retina-specific leucine zipper protein; Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor
CRX
and NR2E3. Binds in a sequence-specific manner to the rhodopsin promoter.
[a.k.a. uc001wlo.4, HPA064599, BX161381]
2) 'ASXL1':
ASXL1
- Polycomb group protein
ASXL1
; Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non- catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK [...]
METTL4 - N(6)-adenine-specific DNA methyltransferase METTL4; N(6)-adenine-specific DNA methyltransferase that mediates methylation of DNA on the 6th position of adenine (N(6)- methyladenosine) and is required to regulate Polycomb silencing. N(6)- methyladenosine deposition by METTL4 triggers ubiquitination and degradation of sensor proteins
ASXL1
and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing; Belongs to the MT-A70-like family.
[a.k.a. ENSP00000319700, ENST00000319888.10, ENST00000319888]