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The following proteins in
Homo sapiens
appear to match your input.
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⤓ Mapping
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1) 'HLA-A':
HLA-A
- HLA class I histocompatibility antigen, A alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells. May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usuall [...]
LILRB2 - Leukocyte immunoglobulin-like receptor subfamily B member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of
HLA
-A,
HLA
-B,
HLA
-C,
HLA
-G and
HLA
-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes
HLA
-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound
HLA
-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FC [...]
[a.k.a. MIR cl-10, ENSP00000320060, LILRB2-208]
LILRB1 - Leukocyte immunoglobulin-like receptor subfamily B member 1; Receptor for class I MHC antigens. Recognizes a broad spectrum of
HLA
-A,
HLA
-B,
HLA
-C,
HLA
-G and
HLA
-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with
HLA
-B or
HLA
-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylatio [...]
[a.k.a. LILRB1-209, ENSP00000379610, CCDS42615.1]
truncated ...
show all 5 options
LILRB4 - Leukocyte immunoglobulin-like receptor subfamily B member 4; Receptor for class I MHC antigens. Recognizes a broad spectrum of
HLA
-A,
HLA
-B,
HLA
-C and
HLA
-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
[a.k.a. NP_001265355, NP_001265355.2, ENSP00000270452]
MEX3C - RNA-binding E3 ubiquitin-protein ligase MEX3C; E3 ubiquitin ligase responsible for the post-transcriptional regulation of common
HLA
-A allotypes. Binds to the 3' UTR of
HLA
-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.
[a.k.a. ENSP00000327398, CCDS11951.2, ENSP00000482566]
2) 'OCA2':
OCA2
- P protein; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Belongs to the CitM (TC 2.A.11) transporter family.