Version:
12.0
Login
Register
Survey
STRING
STRING
Search
Download
Help
My Data
The following proteins in
Homo sapiens
appear to match your input.
Please review the list, then click 'Continue' to proceed.
<- Back
⤓ Mapping
Continue ->
1) 'MTOR':
MTOR
- Serine/threonine-protein kinase
mTOR
; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals.
MTOR
directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (
mTOR
complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF [...]
MEAK7 -
MTOR
-associated protein MEAK7; Activates an alternative
mTOR
signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration. Recruits
MTOR
at the lysosome, essential for
MTOR
signaling at the lysosome.
[a.k.a. XM_017023511, HGNC:29325, URS0000D6EB6F]
SIK3 - Serine/threonine-protein kinase SIK3; Positive regulator of
mTOR
signaling that functions by triggering the degradation of DEPTOR, an
mTOR
inhibitor. Involved in the dynamic regulation of
mTOR
signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
[a.k.a. AP000936, XP_011541027, XP_011541026]
truncated ...
show all 35 options
FBXO9 - F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating
mTOR
signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence,
mTOR
[...]
[a.k.a. R-HSA-8951664, CCDS55024.1, ENST00000484436]
MINAR1 - Major intrinsically disordered Notch2-binding receptor 1; Intrinsically disordered protein which may negatively regulate
mTOR
signaling pathway by stabilizing the
mTOR
complex component DEPTOR. Negatively regulates angiogenesis. Negatively regulates cell growth. Negatively regulates neurite outgrowth in hippocampal neurons (By similarity); Belongs to the MINAR family.
[a.k.a. XP_011519698.1, uc002bew.2, AB028947]
BRAT1 - BRCA1-associated ATM activator 1; Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of
MTOR
and
MTOR
- related proteins, and cell cycle progress by growth factors.
[a.k.a. NP_001337556.1, Q8IW85, BRAT1_HUMAN]
TBCK - TBC domain-containing protein kinase-like protein; Involved in the modulation of
mTOR
signaling and expression of
mTOR
complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization.
[a.k.a. Q6NUP4, XR_001741353, ENSG00000145348]
RPS6KB1 - Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of
mTOR
signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...]
[a.k.a. NP_001356601.1, URS0000EACB8A, 4L43]
FLT3 - Receptor-type tyrosine-protein kinase FLT3; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector
MTOR
. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only m [...]
[a.k.a. NX_P36888, UPI0000D4A161, R-HSA-109704]
PIH1D1 - PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of
MTOR
and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
[a.k.a. NP_060386.1, UPI0002A47748, M0QYF4]
FNIP2 - Folliculin-interacting protein 2; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and
mTOR
signaling pathways. May regulate phosphorylation of RPS6KB1.
[a.k.a. KIAA1450, NP_001332972.1, ENST00000505445.1]
TM4SF5 - Transmembrane 4 L6 family member 5; Acts as a lysosomal membrane arginine sensor. Forms a complex with
MTOR
and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations. Facilitates cell cycle G1/S phase progression and the translocation of the CDK4- CCND1 complex into the nucleus. CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression ; Belongs to the L6 tetraspanin family.
[a.k.a. 9032, ENSP00000270560, AF027204]
FLCN - Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and
mTOR
signaling pathways. May regulate phosphorylation of RPS6KB1.
[a.k.a. XP_011522016, FLCN-203, FLCN-204]
DEPTOR - DEP domain-containing
mTOR
-interacting protein; Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.
[a.k.a. DEP.6, CCDS64960, FLJ12428]
UBR1 - E3 ubiquitin-protein ligase UBR1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-
mTOR
signaling pathway, thereby controlling cell growth; Belongs to the UBR1 family.
[a.k.a. BC113507, UPI0002467177, ENST00000564540]
RICTOR - Rapamycin-insensitive companion of
mTOR
; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activa [...]
[a.k.a. XM_011514005.2, ENST00000357387, NP_001272369]
TSC1 - Hamartin; In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated
mTOR
signaling (By similarity). Acts as a co- chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1. Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 [...]
[a.k.a. ENST00000642646, LAM, A0A2R8Y5M3]
RHEBL1 - GTPase RhebL1; Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through
MTOR
, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.
[a.k.a. RHEB2, ENST00000420065, UPI00001BDA0F]
RPTOR - Regulatory-associated protein of
mTOR
; Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1- TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTO [...]
[a.k.a. Mip1, ENST00000570891.5, R-HSA-9006925]
RPS6KB2 - Ribosomal protein S6 kinase beta-2; Phosphorylates specifically ribosomal protein S6. Seems to act downstream of
mTOR
signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 ; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
[a.k.a. STK14B, R-HSA-9006925, ENST00000525726]
WAC - WW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates
MTOR
activity by promot [...]
[a.k.a. ENST00000375646, ENST00000448193, XP_016871806]
ROS1 - Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-
mTOR
signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation [...]
[a.k.a. XM_011536055, XP_006715611.1, 4UXL]
PLPP7 - Inactive phospholipid phosphatase 7; Plays a role as negative regulator of myoblast differentiation, in part through effects on
MTOR
signaling. Has no detectable enzymatic activity (By similarity).
[a.k.a. ENSP00000361338, ENSP00000292010, C9orf67]
UBR2 - E3 ubiquitin-protein ligase UBR2; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-
mTOR
signaling pathway, thereby controlling cell growth. Required for spermatogenesis, promotes, w [...]
[a.k.a. ENST00000372899.5, ENST00000372903.6, XM_011514441.2]
RPS6KA3 - Ribosomal protein S6 kinase alpha-3; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating
mTOR
signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subseq [...]
[a.k.a. R-HSA-388396, BC096301, XP_011543858]
UBE2QL1 - Ubiquitin-conjugating enzyme E2Q-like protein 1; Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of
MTOR
and CCNE1 through interaction with FBXW7; Belongs to the ubiquitin-conjugating enzyme family.
[a.k.a. A1L167, ENSG00000215218, hsa:134111]
PRR16 - Protein Largen; Regulator of cell size that promotes cell size increase independently of
mTOR
and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration.
[a.k.a. XM_011543453, ENST00000331687, HGNC:29654]
LAPTM4B - Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence
mTOR
[...]
[a.k.a. ENST00000517924, AAL17908.2, NM_018407.6]
DISC1 - Disrupted in schizophrenia 1 protein; Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt- mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-
mTOR
signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, includ [...]
[a.k.a. NP_001158023, FJ804205, NM_001164537.2]
FNIP1 - Folliculin-interacting protein 1; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. May be involved in energy and/or nutrient sensing through the AMPK and
mTOR
signaling pathways. May regulate phosphorylation of RPS6KB1. Belongs to the FNIP family.
[a.k.a. CCDS34227, ENST00000307954, NP_001008738.2]
RPS6KA1 - Ribosomal protein S6 kinase alpha-1; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating
mTOR
signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activa [...]
[a.k.a. R-HSA-388396, hsa:6195, ENST00000531113.5]
PRR14 - Proline-rich protein 14; Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha. Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit. Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha. Involved in the positive regulation of the PI3K-Akt-
mTOR
signaling pathway and in promoting cell proliferation, possibly via binding to GRB2.
[a.k.a. NM_001320464.1, PRR14-206, ENSP00000455835]
TNFAIP8L1 - Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of
mTOR
activity. Belongs to the TNFAIP8 family.
[a.k.a. UPI000013EB11, R-HSA-1483255, R-HSA-556833]
FAM83D - Protein FAM83D; Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of
MTOR
, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.
[a.k.a. XM_017028088.1, Q9BVM8, NM_030919]
FBXW8 - F-box/WD repeat-containing protein 8; Substrate-recognition component of a Cul7-RING ubiquitin- protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7- RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a
mTOR
-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 [...]
[a.k.a. R-HSA-8951664, ENST00000505227, FBXW8-203]
2) 'PTEN':
PTEN
- Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...]
NR2E1 - Nuclear receptor subfamily 2 group E member 1; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates
PTEN
-Cyclin D expression via binding to the promoter region of
PTEN
and suppressing its activity (By similarity). May be involved [...]
[a.k.a. TLX, R-HSA-9006925, NM_001286102]
FRK - Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates
PTEN
protein stability through phosphorylation of
PTEN
on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
[a.k.a. RAK, R-HSA-9006925, ENSG00000111816]
truncated ...
show all 12 options
ABTB1 - Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the
PTEN
growth-suppressive signaling pathway. May play a role in developmental processes.
[a.k.a. NM_172027.3, AK130594, NP_742024.1]
MAGI3 - Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with
PTEN
to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the [...]
[a.k.a. CCDS860.1, Q5TCQ9, OTTHUMG00000011737]
TNS3 - Tensin-3; May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity); Belongs to the
PTEN
phosphatase protein family.
[a.k.a. Tensin 3, AK092864, Q68CZ2]
STK11 - Serine/threonine-protein kinase STK11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA,
PTEN
and possibly p53/TP [...]
[a.k.a. AAC15742.1, XP_005259675.1, K7EMR0]
USP7 - Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1,
PTEN
, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the p [...]
[a.k.a. 7874, R-HSA-6781823, ENSP00000455719]
MAGI2 - Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of
PTEN
to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
[a.k.a. UPI0000EE5731, ENST00000637282.1, XP_011515020.1]
PLK3 - Serine/threonine-protein kinase PLK3; Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73,
PTEN
, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosi [...]
[a.k.a. U56998, ENST00000465443, polo like kinase 3]
PARD3 - Partitioning defective 3 homolog; Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase
PTEN
to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of [...]
[a.k.a. Partitioning defective 3 homolog, R-HSA-170834, ENST00000374790.7]
RSL1D1 - Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of
PTEN
translation. Acts as a pro-apoptotic regulator in response to DNA damage; Belongs to the universal ribosomal protein uL1 family. Highly divergent.
[a.k.a. ENSP00000459207, Q2M1T7, B4DJ58]