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The following proteins in
Homo sapiens
appear to match your input.
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⤓ Mapping
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1) 'MUT':
MMUT - Methylmalonyl-CoA mutase, mitochondrial; Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species; Belongs to the methylmalonyl-CoA mutase family.
[a.k.a. R-HSA-196854, R-HSA-556833, 3BIC,
MUT
]
MSH2 - DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers:
MutS
alpha (MSH2-MSH6 heterodimer) and
MutS
beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs.
MutS
alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA.
MutS
beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding,
MutS
alpha or beta forms a t [...]
[a.k.a. UPI000D1971F5, ENSP00000389452, ENST00000406134]
MLH1 - DNA mismatch repair protein Mlh1; Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by
MutS
alpha (MSH2-MSH6) or
MutS
beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-
MutS
-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing t [...]
[a.k.a. U17843, MLH1-226, ENST00000673713]
truncated ...
show all 12 options
MSH3 - DNA mismatch repair protein Msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form
MutS
beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the
MutS
beta heterodimer bends the DNA helix and shields approximately 20 base pairs.
MutS
beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, a [...]
[a.k.a. AC010270, DNA mismatch repair protein Msh3, 3THW]
PMS2 - Mismatch repair endonuclease PMS2; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by
MutS
alpha (MSH2-MSH6) or
MutS
beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-
MutS
-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing th [...]
[a.k.a. NP_001308940.1, NM_001322010.1, P54278]
MSH6 - DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form
MutS
alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound,
MutS
alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, a [...]
[a.k.a. HPA028446, XP_024308589.1, XP_024308590]
MSH4 -
MutS
protein homolog 4; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis; Belongs to the DNA mismatch repair
MutS
family.
[a.k.a. mutS homolog 4 (E. coli), DNA mismatch repair protein MSH4, R-HSA-1474165]
EXD3 - Exonuclease
mut
-7 homolog; Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity); Belongs to the
mut
-7 family.
[a.k.a. ENST00000479452, XM_011518810.1, 54932]
MSH5 -
MutS
protein homolog 5; Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity); Belongs to the DNA mismatch repair
MutS
family.
[a.k.a. AF070072, ENST00000375755, A0A494C0L0]
CCNB1IP1 - E3 ubiquitin-protein ligase CCNB1IP1; Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with
MutS
-gamma-associated recombination sites and thereby establish early differentiation of crossover and non- crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and
MutS
-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates [...]
[a.k.a. C14orf18, CCNB1IP1-206, CCNB1IP1-203]
RNF212 - Probable E3 SUMO-protein ligase RNF212; SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as
MutS
-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with [...]
[a.k.a. XR_002959724, NR_159502.1, UPI000006EF28]
MMAB - Corrinoid adenosyltransferase; Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to
MUT
in a transfer taht is stimulated by ATP-binding to MMAB and gated by MMAA.
[a.k.a. XP_024304729.1, XP_011536571.1, R-HSA-196854]
2) 'OCA2':
OCA2
- P protein; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Belongs to the CitM (TC 2.A.11) transporter family.