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The following proteins in
Homo sapiens
appear to match your input.
Please review the list, then click 'Continue' to proceed.
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⤓ Mapping
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1) 'SPTBN4':
SPTBN4
- Spectrin beta chain, non-erythrocytic 4.
2) 'PTEN':
PTEN
- Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...]
NR2E1 - Nuclear receptor subfamily 2 group E member 1; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates
PTEN
-Cyclin D expression via binding to the promoter region of
PTEN
and suppressing its activity (By similarity). May be involved [...]
[a.k.a. TLX, R-HSA-9006925, NM_001286102]
FRK - Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates
PTEN
protein stability through phosphorylation of
PTEN
on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
[a.k.a. RAK, R-HSA-9006925, ENSG00000111816]
truncated ...
show all 12 options
ABTB1 - Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the
PTEN
growth-suppressive signaling pathway. May play a role in developmental processes.
[a.k.a. NM_172027.3, AK130594, NP_742024.1]
MAGI3 - Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with
PTEN
to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the [...]
[a.k.a. CCDS860.1, Q5TCQ9, OTTHUMG00000011737]
TNS3 - Tensin-3; May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity); Belongs to the
PTEN
phosphatase protein family.
[a.k.a. Tensin 3, AK092864, Q68CZ2]
STK11 - Serine/threonine-protein kinase STK11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA,
PTEN
and possibly p53/TP [...]
[a.k.a. AAC15742.1, XP_005259675.1, K7EMR0]
USP7 - Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1,
PTEN
, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the p [...]
[a.k.a. 7874, R-HSA-6781823, ENSP00000455719]
MAGI2 - Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of
PTEN
to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
[a.k.a. UPI0000EE5731, ENST00000637282.1, XP_011515020.1]
PLK3 - Serine/threonine-protein kinase PLK3; Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73,
PTEN
, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosi [...]
[a.k.a. U56998, ENST00000465443, polo like kinase 3]
PARD3 - Partitioning defective 3 homolog; Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase
PTEN
to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of [...]
[a.k.a. Partitioning defective 3 homolog, R-HSA-170834, ENST00000374790.7]
RSL1D1 - Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of
PTEN
translation. Acts as a pro-apoptotic regulator in response to DNA damage; Belongs to the universal ribosomal protein uL1 family. Highly divergent.
[a.k.a. ENSP00000459207, Q2M1T7, B4DJ58]