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The following proteins in
Homo sapiens
appear to match your input.
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⤓ Mapping
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1) 'TLR4':
TLR4
- Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non- conserved histidines and are, therefore, species-specific. Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression. In complex with [...]
LY96 - Lymphocyte antigen 96; Binds bacterial lipopolysaccharide (LPS). Cooperates with
TLR4
in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances
TLR4
-dependent activation of NF-kappa-B. Cells expressing both LY96 and
TLR4
, but not
TLR4
alone, respond to LPS.
[a.k.a. R-HSA-2562578, NM_015364, NM_001195797.1]
TICAM2 - TIR domain-containing adapter molecule 2; Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In
TLR4
signaling, physically bridges
TLR4
and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of
TLR4
. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adapt [...]
[a.k.a. R-HSA-2562578, TICAM-2, AAQ97432.1]
truncated ...
show all 26 options
WDFY1 - WD repeat and FYVE domain-containing protein 1; Positively regulates TLR3- and
TLR4
-mediated signaling pathways by bridging the interaction between TLR3 or
TLR4
and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines.
[a.k.a. KIAA1435, WD repeat and FYVE domain-containing protein 1, AF411977]
MFHAS1 - Malignant fibrous histiocytoma-amplified sequence 1; Probable GTP-binding protein. Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and
TLR4
signaling pathways. Negatively regulates the part of the
TLR4
signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor. Both inhibits and activates the TLR2-dependent s [...]
[a.k.a. ENST00000520091.1, XM_024447330.1, Q9Y4C4]
SIGIRR - Single Ig IL-1-related receptor; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor- proximal signaling components to the
TLR4
receptor, probably through an TIR-TIR domain interaction with
TLR4
. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
[a.k.a. NM_001135054.1, ENST00000382520, SIGIRR-216]
TRIL -
TLR4
interactor with leucine rich repeats; Component of the
TLR4
signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion.
[a.k.a. AC005013, NX_Q7L0X0, NM_014817.3]
RAB7B - Ras-related protein Rab-7b; Controls vesicular trafficking from endosomes to the trans- Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates
TLR4
signaling in macrophages by promoting lysosomal degradation of
TLR4
. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation [...]
[a.k.a. MGC16212, NM_001164522, ENST00000617991]
TICAM1 - TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Adapter used by TLR3,
TLR4
(through TICAM2) and TLR5 to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif [...]
[a.k.a. R-HSA-2562578, R-HSA-5602571, R-HSA-9013957]
CD180 - CD180 antigen; May cooperate with MD-1 and
TLR4
to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF- kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).
[a.k.a. OMIM:602226, BC109070, ENST00000515027.1]
TRAFD1 - TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (
TLR4
) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).
[a.k.a. NP_006691, EAW97997.1, F8VWK2]
CNPY4 - Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of
TLR4
.
[a.k.a. CNPY4-205, HPA025240, NP_689968]
MAP3K8 - Mitogen-activated protein kinase kinase kinase 8; Required for lipopolysaccharide (LPS)-induced,
TLR4
-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up- [...]
[a.k.a. Mitogen-activated protein kinase kinase kinase 8, XP_016871196.1, ESTF]
PTPN4 - Tyrosine-protein phosphatase non-receptor type 4; Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates
TLR4
-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membran [...]
[a.k.a. J3KQD3, 5EYZ, NM_002830.4]
RFTN2 - Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of
TLR4
in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling; Belongs to the raftlin family.
[a.k.a. BC111069, RFTN2-202, Q52LD8]
TNIP2 - TNFAIP3-interacting protein 2; Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the
TLR4
signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May ac [...]
[a.k.a. Q9H682, CCDS54714.1, NP_077285]
RFTN1 - Raftlin; Involved in protein trafficking via association with clathrin and AP2 complex. Upon bacterial lipopolysaccharide stimulation, mediates internalization of
TLR4
to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). [...]
[a.k.a. RFTN1-204, ENST00000449415.5, F8WAR1]
NLRC3 - NLR family CARD domain-containing protein 3; Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity). May affect
TLR4
signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-lin [...]
[a.k.a. BAB84935.1, BK001112, XP_016878517]
MAP3K21 - Mitogen-activated protein kinase kinase kinase 21; Negative regulator of
TLR4
signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
[a.k.a. Q5TCX8, BAB47433.1, NM_032435]
SASH1 - SAM and SH3 domain-containing protein 1; Is a positive regulator of NF-kappa-B signaling downstream of
TLR4
activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.
[a.k.a. AY351964, SAM and SH3 domain containing 1, SASH1-206]
ZFAND5 - AN1-type zinc finger protein 5; Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and
TLR4
-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent [...]
[a.k.a. ZA20D2, NM_001102420.3, ENSG00000107372]
LY86 - Lymphocyte antigen 86; May cooperate with CD180 and
TLR4
to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity).
[a.k.a. Ly-86, dJ80N2.1, LY86-202]
RNF216 - E3 ubiquitin-protein ligase RNF216; Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3,
TLR4
and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.
[a.k.a. XP_024302574, AAP47175.1, ENST00000476345.1]
TIRAP - Toll/interleukin-1 receptor domain-containing adapter protein; Adapter involved in TLR2 and
TLR4
signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
[a.k.a. NM_001039661, EAW67687.1, TIRAP-206]
INAVA - Innate immunity activator protein; Expressed in peripheral macrophages and intestinal myeloid- derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3,
TLR4
, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulate [...]
[a.k.a. INAVA-203, ENSP00000392105, NM_001367289]
TNIP3 - TNFAIP3-interacting protein 3; Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (
TLR4
), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
[a.k.a. AK024815, NM_001244764.1, XP_016864108.1]
2) 'OCA2':
OCA2
- P protein; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Belongs to the CitM (TC 2.A.11) transporter family.