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The following proteins in
Homo sapiens
appear to match your input.
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1) 'XPC':
XPC
- DNA repair protein complementing XP-C cells; Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the
XPC
complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function:
XPC
can rapidly screen duplex DNA for non-hydrogen- bonded bases by forming a transient nucleoprotein intermediate complex which matures in [...]
CETN2 - Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The
XPC
complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The
XPC
complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...]
[a.k.a. NM_004344, R-HSA-5696395, NM_004344.3]
RAD23B - UV excision repair protein RAD23 homolog B; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. The
XPC
complex is proposed to represent the first factor bound at the sites of DNA damage a [...]
[a.k.a. ENST00000358015, P54727, R-HSA-5696395]
2) 'ASXL1':
ASXL1
- Polycomb group protein
ASXL1
; Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non- catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK [...]
METTL4 - N(6)-adenine-specific DNA methyltransferase METTL4; N(6)-adenine-specific DNA methyltransferase that mediates methylation of DNA on the 6th position of adenine (N(6)- methyladenosine) and is required to regulate Polycomb silencing. N(6)- methyladenosine deposition by METTL4 triggers ubiquitination and degradation of sensor proteins
ASXL1
and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing; Belongs to the MT-A70-like family.
[a.k.a. ENSP00000319700, ENST00000319888.10, ENST00000319888]