splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes: protein of unknown 3D structure
large nodes: some 3D structure is known or predicted
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PVX_111035
aspartyl protease (479 aa)
Predicted Functional Partners:
PVX_092460
subtilisin-like protease 2 (1410 aa)
0.723
PVX_117890
sortilin (898 aa)
0.649
PVX_084620
polyubiquitin 5 (381 aa)
0.452
Your Current Organism:
Plasmodium vivax
NCBI taxonomy Id: 5855 Other names: P. vivax, Plasmodium vivax, malaria parasite P. vivax
Genes that are sometimes fused into single open reading frames.
Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network Stats
Network Stats analysis is still ongoing, please wait ...
Functional enrichments in your networkNote: some enrichments may be expected here (why?)
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: