| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SPCC1281.06c.1 | erv25 | SPCC1281.06c.1 | SPAC23H4.03c.1 | acyl-coA desaturase (predicted); Utilizes O(2) and electrons from the reduced cytochrome b(5) domain to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates (By similarity) | COPII-coated vesicle component Erv25 (predicted); Constituent of COPII-coated endoplasmic reticulum- derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity) | 0.744 |
| SPCC1281.06c.1 | sec11 | SPCC1281.06c.1 | SPBC1685.03.1 | acyl-coA desaturase (predicted); Utilizes O(2) and electrons from the reduced cytochrome b(5) domain to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates (By similarity) | signal peptidase subunit Sec11 (predicted); Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity) | 0.773 |
| SPCC1281.06c.1 | spc2 | SPCC1281.06c.1 | SPAC1071.04c.1 | acyl-coA desaturase (predicted); Utilizes O(2) and electrons from the reduced cytochrome b(5) domain to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates (By similarity) | signal peptidase subunit Spc2 (predicted); Nonessential component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum. Spc2 enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity) | 0.856 |
| SPCC1281.06c.1 | spc3 | SPCC1281.06c.1 | SPAC56F8.11.1 | acyl-coA desaturase (predicted); Utilizes O(2) and electrons from the reduced cytochrome b(5) domain to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates (By similarity) | signal peptidase subunit Spc3 (predicted); Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | 0.886 |
| SPCC1281.06c.1 | ubi4 | SPCC1281.06c.1 | SPBC337.08c.1 | acyl-coA desaturase (predicted); Utilizes O(2) and electrons from the reduced cytochrome b(5) domain to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates (By similarity) | ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; Lys-11- [...] | 0.932 |
| dcr1 | mrpl8 | SPCC188.13c.1 | SPBC1271.13.1 | dicer; Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2 | mitochondrial ribosomal protein subunit L8 (predicted) | 0.625 |
| dcr1 | sec11 | SPCC188.13c.1 | SPBC1685.03.1 | dicer; Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2 | signal peptidase subunit Sec11 (predicted); Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity) | 0.841 |
| dcr1 | ubi4 | SPCC188.13c.1 | SPBC337.08c.1 | dicer; Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2 | ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; Lys-11- [...] | 0.636 |
| erv25 | SPCC1281.06c.1 | SPAC23H4.03c.1 | SPCC1281.06c.1 | COPII-coated vesicle component Erv25 (predicted); Constituent of COPII-coated endoplasmic reticulum- derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity) | acyl-coA desaturase (predicted); Utilizes O(2) and electrons from the reduced cytochrome b(5) domain to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates (By similarity) | 0.744 |
| erv25 | ost3 | SPAC23H4.03c.1 | SPAPB17E12.11.1 | COPII-coated vesicle component Erv25 (predicted); Constituent of COPII-coated endoplasmic reticulum- derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity) | oligosaccharyltransferase gamma subunit Ost3 (predicted); Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (By similarity) | 0.868 |
| erv25 | sbh1 | SPAC23H4.03c.1 | SPBC2G2.03c.1 | COPII-coated vesicle component Erv25 (predicted); Constituent of COPII-coated endoplasmic reticulum- derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity) | translocon beta subunit Sbh1 (predicted); Necessary for protein translocation in the endoplasmic reticulum (By similarity) | 0.656 |
| erv25 | sec11 | SPAC23H4.03c.1 | SPBC1685.03.1 | COPII-coated vesicle component Erv25 (predicted); Constituent of COPII-coated endoplasmic reticulum- derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity) | signal peptidase subunit Sec11 (predicted); Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity) | 0.999 |
| erv25 | spc2 | SPAC23H4.03c.1 | SPAC1071.04c.1 | COPII-coated vesicle component Erv25 (predicted); Constituent of COPII-coated endoplasmic reticulum- derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity) | signal peptidase subunit Spc2 (predicted); Nonessential component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum. Spc2 enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity) | 0.845 |
| erv25 | ubi4 | SPAC23H4.03c.1 | SPBC337.08c.1 | COPII-coated vesicle component Erv25 (predicted); Constituent of COPII-coated endoplasmic reticulum- derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity) | ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; Lys-11- [...] | 0.875 |
| mrpl8 | dcr1 | SPBC1271.13.1 | SPCC188.13c.1 | mitochondrial ribosomal protein subunit L8 (predicted) | dicer; Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2 | 0.625 |
| mrpl8 | nup107 | SPBC1271.13.1 | SPBC428.01c.1 | mitochondrial ribosomal protein subunit L8 (predicted) | nucleoporin Nup107; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope | 0.717 |
| mrpl8 | sec11 | SPBC1271.13.1 | SPBC1685.03.1 | mitochondrial ribosomal protein subunit L8 (predicted) | signal peptidase subunit Sec11 (predicted); Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity) | 0.781 |
| nup107 | mrpl8 | SPBC428.01c.1 | SPBC1271.13.1 | nucleoporin Nup107; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope | mitochondrial ribosomal protein subunit L8 (predicted) | 0.717 |
| nup107 | sec11 | SPBC428.01c.1 | SPBC1685.03.1 | nucleoporin Nup107; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope | signal peptidase subunit Sec11 (predicted); Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity) | 0.798 |
| nup107 | ubi4 | SPBC428.01c.1 | SPBC337.08c.1 | nucleoporin Nup107; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope | ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; Lys-11- [...] | 0.885 |
