Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
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 | erg27 | 3-keto sterol reductase (predicted); Responsible for the reduction of the keto group on the C-3 of sterols (By similarity) (338 aa) | ||||||||||||
Predicted Functional Partners:
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 | erg26 | 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase (predicted) (340 aa) |
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0.998 | |||||||
 | erg7 | lanosterol synthase Erg7 (predicted); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (721 aa) |
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0.991 | ||||||||
 | erg25 | C-4 methylsterol oxidase (predicted); Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol (By similarity) (300 aa) |
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0.981 | |||||||
 | erg6 | sterol 24-C-methyltransferase Erg6; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins (378 aa) |
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0.977 | ||||||||
 | erg11 | sterol 14-demethylase (predicted); Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity) (495 aa) |
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0.977 | |||||||
 | erg28 | Erg28 protein (predicted); May have a role in anchoring erg26 and erg27 to the endoplasmic reticulum. May also be responsible for facilitating their interaction (By similarity) (136 aa) |
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0.966 | ||||||||
 | erg24 | C-14 sterol reductase Erg24 (predicted); Reduces the C14=C15 double bond of 4,4-dimethyl- cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24- dienol (By similarity) (424 aa) |
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0.963 | |||||||||
 | sts1 | C-24(28) sterol reductase Sts1 (453 aa) |
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0.963 | |||||||||
 | SPAC1B3.06c.1 | UbiE family methyltransferase (predicted); Probable methyltransferase (By similarity) (278 aa) |
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0.939 | ||||||||
 | erg9 | squalene synthase Erg9 (predicted); Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol (460 aa) |
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0.939 | ||||||||
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 4896
Other names: S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
Other names: S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
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