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STRINGSTRING
RABL2A RABL2A RAB25 RAB25 STX16 STX16 ENSG00000254995 ENSG00000254995 EFS EFS RABL2B RABL2B TRAPPC6B TRAPPC6B RAB3IP RAB3IP RAB11A RAB11A TRAPPC5 TRAPPC5 RAB11B RAB11B HOXA1 HOXA1 TRAPPC2P1 TRAPPC2P1 TRAPPC10 TRAPPC10 TRAPPC6A TRAPPC6A TRAPPC1 TRAPPC1 RAD54B RAD54B TRAPPC2 TRAPPC2 FSBP FSBP TRAPPC4 TRAPPC4 TRAPPC3 TRAPPC3 TRAPPC8 TRAPPC8 SSSCA1 SSSCA1 BET3L BET3L TRAPPC2L TRAPPC2L TRAPPC12 TRAPPC12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
TRAPPC6Atrafficking protein particle complex 6A; May play a role in vesicular transport during the biogenesis of melanosomes (By similarity) (173 aa)
EFSembryonal Fyn-associated substrate; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity) (561 aa)
RAB11ARAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] (216 aa)
TRAPPC8trafficking protein particle complex 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (1435 aa)
TRAPPC10trafficking protein particle complex 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi (1259 aa)
TRAPPC2Ltrafficking protein particle complex 2-like; May play a role in vesicular transport from endoplasmic reticulum to Golgi (140 aa)
TRAPPC1trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi (145 aa)
SSSCA1Sjogren syndrome/scleroderma autoantigen 1; Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies (199 aa)
TRAPPC5trafficking protein particle complex 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi (188 aa)
TRAPPC12trafficking protein particle complex 12; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (735 aa)
TRAPPC6Btrafficking protein particle complex 6B; May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) (158 aa)
RAB11BRAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) (218 aa)
RAD54BRAD54 homolog B (S. cerevisiae); Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group (910 aa)
HOXA1homeobox A1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (335 aa)
RAB25RAB25, member RAS oncogene family; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity) (213 aa)
BET3LBET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) (181 aa)
STX16syntaxin 16 (325 aa)
TRAPPC3trafficking protein particle complex 3; May play a role in vesicular transport from endoplasmic reticulum to Golgi (180 aa)
RABL2ARAB, member of RAS oncogene family-like 2A (228 aa)
RABL2BRAB, member of RAS oncogene family-like 2B (238 aa)
TRAPPC2trafficking protein particle complex 2; Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi (174 aa)
FSBPfibrinogen silencer binding protein; Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1 (299 aa)
TRAPPC4trafficking protein particle complex 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi (219 aa)
TRAPPC2P1trafficking protein particle complex 2 pseudogene 1; Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi (140 aa)
RAB3IPRAB3A interacting protein (rabin3) (476 aa)
ENSG00000254995STX16-NPEPL1 readthrough (non-protein coding) (382 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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