node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEACAM1 | CEACAM6 | ENSP00000161559 | ENSP00000199764 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.970 |
CEACAM1 | PTPN11 | ENSP00000161559 | ENSP00000340944 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.894 |
CEACAM6 | CEACAM1 | ENSP00000199764 | ENSP00000161559 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.970 |
PLCB1 | PLCB2 | ENSP00000338185 | ENSP00000260402 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.904 |
PLCB1 | PLCB3 | ENSP00000338185 | ENSP00000279230 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.902 |
PLCB1 | PLCB4 | ENSP00000338185 | ENSP00000334105 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, beta 4 | 0.905 |
PLCB1 | PLCD1 | ENSP00000338185 | ENSP00000430344 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, delta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development | 0.914 |
PLCB1 | PLCD3 | ENSP00000338185 | ENSP00000313731 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, delta 3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow | 0.913 |
PLCB1 | PLCD4 | ENSP00000338185 | ENSP00000388631 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, delta 4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overex [...] | 0.910 |
PLCB1 | PLCE1 | ENSP00000338185 | ENSP00000260766 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, epsilon 1 | 0.911 |
PLCB1 | PLCZ1 | ENSP00000338185 | ENSP00000266505 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, zeta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg [...] | 0.904 |
PLCB2 | PLCB1 | ENSP00000260402 | ENSP00000338185 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, beta 1 (phosphoinositide-specific) | 0.904 |
PLCB2 | PLCB3 | ENSP00000260402 | ENSP00000279230 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.905 |
PLCB2 | PLCB4 | ENSP00000260402 | ENSP00000334105 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, beta 4 | 0.907 |
PLCB2 | PLCD1 | ENSP00000260402 | ENSP00000430344 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, delta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development | 0.912 |
PLCB2 | PLCD3 | ENSP00000260402 | ENSP00000313731 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, delta 3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow | 0.909 |
PLCB2 | PLCD4 | ENSP00000260402 | ENSP00000388631 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, delta 4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overex [...] | 0.913 |
PLCB2 | PLCE1 | ENSP00000260402 | ENSP00000260766 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, epsilon 1 | 0.913 |
PLCB2 | PLCZ1 | ENSP00000260402 | ENSP00000266505 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, zeta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg [...] | 0.901 |
PLCB3 | PLCB1 | ENSP00000279230 | ENSP00000338185 | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, beta 1 (phosphoinositide-specific) | 0.902 |