Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | RHBDD2 | rhomboid domain containing 2 (364 aa) | ||
 | MKRN2 | makorin ring finger protein 2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity) (416 aa) | ||
 | GSTT2 | glutathione S-transferase theta 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity (244 aa) | ||
 | GSTZ1 | glutathione S-transferase zeta 1 (216 aa) | ||
 | WASL | Wiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (505 aa) | ||
 | GORASP2 | golgi reassembly stacking protein 2, 55kDa; Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (452 aa) | ||
 | GSTT1 | glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide (240 aa) | ||
 | SLC31A2 | solute carrier family 31 (copper transporters), member 2; Involved in low-affinity copper uptake (Potential) (143 aa) | ||
 | MARS | methionyl-tRNA synthetase (900 aa) | ||
 | ZC3H3 | zinc finger CCCH-type containing 3 (948 aa) | ||
 | GSTT2B | glutathione S-transferase theta 2B (gene/pseudogene); Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity (244 aa) | ||
 | CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) (269 aa) | ||
 | EEF1G | eukaryotic translation elongation factor 1 gamma; Probably plays a role in anchoring the complex to other cellular components (437 aa) | ||
 | CPSF4L | cleavage and polyadenylation specific factor 4-like (179 aa) | ||
 | SLC31A1 | solute carrier family 31 (copper transporters), member 1; High-affinity, saturable copper transporter involved in dietary copper uptake (190 aa) | ||
 | VARS | valyl-tRNA synthetase (1264 aa) | ||
 | TM9SF2 | transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter (663 aa) | ||
 | EEF1E1 | eukaryotic translation elongation factor 1 epsilon 1; Positive modulator of ATM response to DNA damage (174 aa) | ||
 | CTNS | cystinosin, lysosomal cystine transporter; Thought to transport cystine out of lysosomes (400 aa) | ||
 | AIMP3 | HCG2043275; Uncharacterized protein (151 aa) | ||
 | TM9SF4 | transmembrane 9 superfamily protein member 4 (642 aa) | ||
 | ZC3H8 | zinc finger CCCH-type containing 8; Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5’-AGGTCTC-3’ sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis (291 aa) | ||
 | ZC3H6 | zinc finger CCCH-type containing 6 (1189 aa) | ||
 | ENSG00000232856 | hsa-mir-3654 (206 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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