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RPLP1 RPLP1 EIF3C EIF3C MRPS12 MRPS12 USP42 USP42 RPS5 RPS5 MRPS15 MRPS15 MRPS2 MRPS2 MRPL42 MRPL42 MRPS5 MRPS5 METTL17 METTL17 MRPS10 MRPS10 MRPS16 MRPS16 MRPS9 MRPS9 MRPS26 MRPS26 LRPPRC LRPPRC HIBCH HIBCH MRPS35 MRPS35 MRPS7 MRPS7 DAP3 DAP3 ABCC2 ABCC2 UQCRFS1 UQCRFS1 LAMTOR3 LAMTOR3 ATP6V1C1 ATP6V1C1 MRPS22 MRPS22 MRPS25 MRPS25 SLC1A5 SLC1A5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MRPS10mitochondrial ribosomal protein S10 (201 aa)
MRPS35mitochondrial ribosomal protein S35 (323 aa)
RPS5ribosomal protein S5 (204 aa)
MRPS2mitochondrial ribosomal protein S2 (296 aa)
MRPS7mitochondrial ribosomal protein S7 (242 aa)
MRPS25mitochondrial ribosomal protein S25 (173 aa)
MRPS9mitochondrial ribosomal protein S9 (396 aa)
LRPPRCleucine-rich pentatricopeptide repeat containing; May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondria [...] (1394 aa)
MRPS5mitochondrial ribosomal protein S5 (430 aa)
USP42ubiquitin specific peptidase 42; Deubiquitinating enzyme which may play an important role during spermatogenesis (By similarity) (1316 aa)
UQCRFS1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (274 aa)
MRPS12mitochondrial ribosomal protein S12 (138 aa)
MRPS22mitochondrial ribosomal protein S22 (360 aa)
EIF3Ceukaryotic translation initiation factor 3, subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] (913 aa)
DAP3death associated protein 3; Involved in mediating interferon-gamma-induced cell death (398 aa)
RPLP1ribosomal protein, large, P1; Plays an important role in the elongation step of protein synthesis (114 aa)
HIBCH3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (386 aa)
ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter (1545 aa)
MRPS16mitochondrial ribosomal protein S16 (137 aa)
MRPS15mitochondrial ribosomal protein S15 (257 aa)
MRPS26mitochondrial ribosomal protein S26 (205 aa)
METTL17methyltransferase like 17; May be a component of the mitochondrial small ribosomal subunit (By similarity) (478 aa)
ATP6V1C1ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (382 aa)
LAMTOR3late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] (124 aa)
SLC1A5solute carrier family 1 (neutral amino acid transporter), member 5 (541 aa)
MRPL42mitochondrial ribosomal protein L42 (142 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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