Your Input:
|
||||
KCNQ1 | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] (676 aa) | |||
KCNA5 | potassium voltage-gated channel, shaker-related subfamily, member 5; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inacti [...] (613 aa) | |||
KCNQ4 | potassium voltage-gated channel, KQT-like subfamily, member 4; Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors (695 aa) | |||
KCNC1 | potassium voltage-gated channel, Shaw-related subfamily, member 1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (585 aa) | |||
KCNA6 | potassium voltage-gated channel, shaker-related subfamily, member 6; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (529 aa) | |||
KCNS2 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) (477 aa) | |||
KCNV1 | potassium channel, subfamily V, member 1; Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (500 aa) | |||
KCNAB3 | potassium voltage-gated channel, shaker-related subfamily, beta member 3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5 (404 aa) | |||
KCNS3 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) (491 aa) | |||
KCNS1 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) (526 aa) | |||
KCNG4 | potassium voltage-gated channel, subfamily G, member 4; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (519 aa) | |||
KCNA2 | potassium voltage-gated channel, shaker-related subfamily, member 2; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (499 aa) | |||
KCNA4 | potassium voltage-gated channel, shaker-related subfamily, member 4; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (653 aa) | |||
KCND2 | potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (630 aa) | |||
KCNE1 | potassium voltage-gated channel, Isk-related family, member 1; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (129 aa) | |||
KCNQ5 | potassium voltage-gated channel, KQT-like subfamily, member 5 (951 aa) | |||
KCNA3 | potassium voltage-gated channel, shaker-related subfamily, member 3; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (575 aa) | |||
KCNA10 | potassium voltage-gated channel, shaker-related subfamily, member 10; Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP (511 aa) | |||
KCNC4 | potassium voltage-gated channel, Shaw-related subfamily, member 4; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (635 aa) | |||
KCNG1 | potassium voltage-gated channel, subfamily G, member 1; Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity (513 aa) | |||
KCNB1 | potassium voltage-gated channel, Shab-related subfamily, member 1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient (858 aa) | |||
KCNA1 | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia); Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (495 aa) | |||
KCNAB1 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 (419 aa) | |||
KCNB2 | potassium voltage-gated channel, Shab-related subfamily, member 2; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient (911 aa) | |||
KCNC3 | potassium voltage-gated channel, Shaw-related subfamily, member 3; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (757 aa) | |||
KCNC2 | potassium voltage-gated channel, Shaw-related subfamily, member 2; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly (By similarity) (638 aa) |