node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUX1 | GOLGA5 | ENSP00000353401 | ENSP00000163416 | cut-like homeobox 1; May be involved in intra-Golgi retrograde transport | golgin A5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | 0.827 |
ENSG00000256861 | GOLGA5 | ENSP00000454454 | ENSP00000163416 | Uncharacterized protein | golgin A5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | 0.661 |
ENSG00000256861 | SCFD1 | ENSP00000454454 | ENSP00000390783 | Uncharacterized protein | sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity) | 0.495 |
ENSG00000256861 | STXBP1 | ENSP00000454454 | ENSP00000362399 | Uncharacterized protein | syntaxin binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1-1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions | 0.500 |
ENSG00000256861 | STXBP2 | ENSP00000454454 | ENSP00000221283 | Uncharacterized protein | syntaxin binding protein 2; Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N- ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells | 0.500 |
ENSG00000256861 | STXBP3 | ENSP00000454454 | ENSP00000359025 | Uncharacterized protein | syntaxin binding protein 3; Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity) | 0.500 |
GOLGA5 | CUX1 | ENSP00000163416 | ENSP00000353401 | golgin A5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | cut-like homeobox 1; May be involved in intra-Golgi retrograde transport | 0.827 |
GOLGA5 | ENSG00000256861 | ENSP00000163416 | ENSP00000454454 | golgin A5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | Uncharacterized protein | 0.661 |
GOLGA5 | OCRL | ENSP00000163416 | ENSP00000360154 | golgin A5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | oculocerebrorenal syndrome of Lowe | 0.768 |
GOLGA5 | RAB1A | ENSP00000163416 | ENSP00000387286 | golgin A5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity | 0.982 |
GOLGA5 | SYNE1 | ENSP00000163416 | ENSP00000356224 | golgin A5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | spectrin repeat containing, nuclear envelope 1 | 0.576 |
GOLGA5 | VPS33A | ENSP00000163416 | ENSP00000267199 | golgin A5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | vacuolar protein sorting 33 homolog A (S. cerevisiae); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (By similarity) | 0.661 |
GOLGA5 | VPS33B | ENSP00000163416 | ENSP00000327650 | golgin A5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | vacuolar protein sorting 33 homolog B (yeast); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages | 0.685 |
ITSN1 | OCRL | ENSP00000370719 | ENSP00000360154 | intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1 | oculocerebrorenal syndrome of Lowe | 0.919 |
OCRL | GOLGA5 | ENSP00000360154 | ENSP00000163416 | oculocerebrorenal syndrome of Lowe | golgin A5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | 0.768 |
OCRL | ITSN1 | ENSP00000360154 | ENSP00000370719 | oculocerebrorenal syndrome of Lowe | intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1 | 0.919 |
OCRL | RAB1A | ENSP00000360154 | ENSP00000387286 | oculocerebrorenal syndrome of Lowe | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity | 0.948 |
RAB1A | GOLGA5 | ENSP00000387286 | ENSP00000163416 | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity | golgin A5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | 0.982 |
RAB1A | OCRL | ENSP00000387286 | ENSP00000360154 | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity | oculocerebrorenal syndrome of Lowe | 0.948 |
RAB1A | SCFD1 | ENSP00000387286 | ENSP00000390783 | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity | sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity) | 0.969 |