node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DMWD | P4HA2 | ENSP00000270223 | ENSP00000166534 | dystrophia myotonica, WD repeat containing; Could have a regulatory function in meiosis | prolyl 4-hydroxylase, alpha polypeptide II; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | 0.740 |
DMWD | UBC | ENSP00000270223 | ENSP00000344818 | dystrophia myotonica, WD repeat containing; Could have a regulatory function in meiosis | ubiquitin C | 0.650 |
FHL3 | UBC | ENSP00000362107 | ENSP00000344818 | four and a half LIM domains 3 | ubiquitin C | 0.925 |
H2AFX | UBC | ENSP00000364310 | ENSP00000344818 | H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in resp [...] | ubiquitin C | 0.999 |
IRS4 | UBC | ENSP00000361202 | ENSP00000344818 | insulin receptor substrate 4; Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kina [...] | ubiquitin C | 0.629 |
LAP3 | P4HA2 | ENSP00000226299 | ENSP00000166534 | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | prolyl 4-hydroxylase, alpha polypeptide II; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | 0.900 |
LAP3 | P5CR2 | ENSP00000226299 | ENSP00000414068 | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | Uncharacterized protein | 0.908 |
LAP3 | PYCR1 | ENSP00000226299 | ENSP00000328858 | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | pyrroline-5-carboxylate reductase 1; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress | 0.929 |
LAP3 | PYCRL | ENSP00000226299 | ENSP00000220966 | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | pyrroline-5-carboxylate reductase-like | 0.908 |
LAP3 | UBC | ENSP00000226299 | ENSP00000344818 | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | ubiquitin C | 0.820 |
MYCBPAP | P4HA2 | ENSP00000323184 | ENSP00000166534 | MYCBP associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity) | prolyl 4-hydroxylase, alpha polypeptide II; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | 0.669 |
P4HA2 | DMWD | ENSP00000166534 | ENSP00000270223 | prolyl 4-hydroxylase, alpha polypeptide II; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | dystrophia myotonica, WD repeat containing; Could have a regulatory function in meiosis | 0.740 |
P4HA2 | LAP3 | ENSP00000166534 | ENSP00000226299 | prolyl 4-hydroxylase, alpha polypeptide II; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | 0.900 |
P4HA2 | MYCBPAP | ENSP00000166534 | ENSP00000323184 | prolyl 4-hydroxylase, alpha polypeptide II; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | MYCBP associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity) | 0.669 |
P4HA2 | P4HB | ENSP00000166534 | ENSP00000327801 | prolyl 4-hydroxylase, alpha polypeptide II; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | prolyl 4-hydroxylase, beta polypeptide; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with [...] | 0.908 |
P4HA2 | P5CR2 | ENSP00000166534 | ENSP00000414068 | prolyl 4-hydroxylase, alpha polypeptide II; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | Uncharacterized protein | 0.900 |
P4HA2 | PRODH2 | ENSP00000166534 | ENSP00000301175 | prolyl 4-hydroxylase, alpha polypeptide II; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | proline dehydrogenase (oxidase) 2; Converts proline to delta-1-pyrroline-5-carboxylate (Probable) | 0.900 |
P4HA2 | PRRC2A | ENSP00000166534 | ENSP00000365175 | prolyl 4-hydroxylase, alpha polypeptide II; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | proline-rich coiled-coil 2A | 0.615 |
P4HA2 | PYCR1 | ENSP00000166534 | ENSP00000328858 | prolyl 4-hydroxylase, alpha polypeptide II; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | pyrroline-5-carboxylate reductase 1; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress | 0.900 |
P4HA2 | PYCRL | ENSP00000166534 | ENSP00000220966 | prolyl 4-hydroxylase, alpha polypeptide II; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | pyrroline-5-carboxylate reductase-like | 0.900 |