node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAA1 | ACAT1 | ENSP00000333664 | ENSP00000265838 | acetyl-CoA acyltransferase 1 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 0.924 |
ACAA1 | ACAT2 | ENSP00000333664 | ENSP00000356015 | acetyl-CoA acyltransferase 1 | acetyl-CoA acetyltransferase 2 | 0.911 |
ACAA2 | ACAT1 | ENSP00000285093 | ENSP00000265838 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 0.972 |
ACAA2 | ACAT2 | ENSP00000285093 | ENSP00000356015 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | acetyl-CoA acetyltransferase 2 | 0.908 |
ACAA2 | HSD17B10 | ENSP00000285093 | ENSP00000168216 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | hydroxysteroid (17-beta) dehydrogenase 10; Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) | 0.493 |
ACAT1 | ACAA1 | ENSP00000265838 | ENSP00000333664 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | acetyl-CoA acyltransferase 1 | 0.924 |
ACAT1 | ACAA2 | ENSP00000265838 | ENSP00000285093 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 0.972 |
ACAT1 | ACAT2 | ENSP00000265838 | ENSP00000356015 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | acetyl-CoA acetyltransferase 2 | 0.841 |
ACAT1 | HADHB | ENSP00000265838 | ENSP00000325136 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit | 0.929 |
ACAT2 | ACAA1 | ENSP00000356015 | ENSP00000333664 | acetyl-CoA acetyltransferase 2 | acetyl-CoA acyltransferase 1 | 0.911 |
ACAT2 | ACAA2 | ENSP00000356015 | ENSP00000285093 | acetyl-CoA acetyltransferase 2 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 0.908 |
ACAT2 | ACAT1 | ENSP00000356015 | ENSP00000265838 | acetyl-CoA acetyltransferase 2 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 0.841 |
ACAT2 | HADHB | ENSP00000356015 | ENSP00000325136 | acetyl-CoA acetyltransferase 2 | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit | 0.937 |
APP | HADHB | ENSP00000284981 | ENSP00000325136 | amyloid beta (A4) precursor protein | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit | 0.576 |
APP | HSD17B10 | ENSP00000284981 | ENSP00000168216 | amyloid beta (A4) precursor protein | hydroxysteroid (17-beta) dehydrogenase 10; Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) | 0.576 |
ARHGDIA | ARHGDIB | ENSP00000269321 | ENSP00000228945 | Rho GDP dissociation inhibitor (GDI) alpha; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity) | Rho GDP dissociation inhibitor (GDI) beta; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | 0.901 |
ARHGDIA | ARHGDIG | ENSP00000269321 | ENSP00000219409 | Rho GDP dissociation inhibitor (GDI) alpha; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity) | Rho GDP dissociation inhibitor (GDI) gamma; Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP | 0.902 |
ARHGDIB | ARHGDIA | ENSP00000228945 | ENSP00000269321 | Rho GDP dissociation inhibitor (GDI) beta; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | Rho GDP dissociation inhibitor (GDI) alpha; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity) | 0.901 |
ARHGDIB | ARHGDIG | ENSP00000228945 | ENSP00000219409 | Rho GDP dissociation inhibitor (GDI) beta; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | Rho GDP dissociation inhibitor (GDI) gamma; Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP | 0.903 |
ARHGDIG | ARHGDIA | ENSP00000219409 | ENSP00000269321 | Rho GDP dissociation inhibitor (GDI) gamma; Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP | Rho GDP dissociation inhibitor (GDI) alpha; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity) | 0.902 |