Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | ADAM7 | ADAM metallopeptidase domain 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity) (754 aa) | ||
 | SPINT3 | serine peptidase inhibitor, Kunitz type, 3 (89 aa) | ||
 | MPP6 | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) (540 aa) | ||
 | CARD10 | caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK (1032 aa) | ||
 | CLEC2D | C-type lectin domain family 2, member D; Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans (194 aa) | ||
 | MPP5 | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) (675 aa) | ||
 | MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (552 aa) | ||
 | SPINT4 | serine peptidase inhibitor, Kunitz type 4 (99 aa) | ||
 | LRGUK | leucine-rich repeats and guanylate kinase domain containing (825 aa) | ||
 | DLG4 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) (767 aa) | ||
 | MPP7 | membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7); Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (576 aa) | ||
 | CARD14 | caspase recruitment domain family, member 14; Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 (1004 aa) | ||
 | CLEC12B | C-type lectin domain family 12, member B; Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases (276 aa) | ||
 | DLG1 | discs, large homolog 1 (Drosophila) (926 aa) | ||
 | CLEC12A | C-type lectin domain family 12, member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases (275 aa) | ||
 | C4BPA | complement component 4 binding protein, alpha; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component (597 aa) | ||
 | MPP1 | membrane protein, palmitoylated 1, 55kDa; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity) (466 aa) | ||
 | DLG3 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (817 aa) | ||
 | DLG2 | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) (975 aa) | ||
 | CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) (921 aa) | ||
 | MPP3 | membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) (585 aa) | ||
 | SVEP1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (3571 aa) | ||
 | MPP4 | membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4); May play a role in retinal photoreceptors development (By similarity) (637 aa) | ||
 | ACAN | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region (2530 aa) | ||
 | GAS7 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons (476 aa) | ||
 | CLEC5A | C-type lectin domain family 5, member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release (188 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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