node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC37 | UBC | ENSP00000222005 | ENSP00000344818 | cell division cycle 37 homolog (S. cerevisiae); Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity | ubiquitin C | 0.992 |
CDR2 | UBC | ENSP00000268383 | ENSP00000344818 | cerebellar degeneration-related protein 2, 62kDa | ubiquitin C | 0.595 |
GRSF1 | MRPL28 | ENSP00000254799 | ENSP00000199706 | G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element | mitochondrial ribosomal protein L28 | 0.504 |
GRSF1 | MRPS7 | ENSP00000254799 | ENSP00000245539 | G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element | mitochondrial ribosomal protein S7 | 0.481 |
GRSF1 | UBC | ENSP00000254799 | ENSP00000344818 | G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element | ubiquitin C | 0.878 |
HTR2A | MRPL28 | ENSP00000367959 | ENSP00000199706 | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production | mitochondrial ribosomal protein L28 | 0.572 |
ICT1 | ILF2 | ENSP00000301585 | ENSP00000355011 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus | 0.607 |
ICT1 | MRPL23 | ENSP00000301585 | ENSP00000370930 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L23 | 0.951 |
ICT1 | MRPL32 | ENSP00000301585 | ENSP00000223324 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L32 | 0.480 |
ICT1 | MRPS7 | ENSP00000301585 | ENSP00000245539 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein S7 | 0.782 |
ICT1 | NPM1 | ENSP00000301585 | ENSP00000296930 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.501 |
ICT1 | TP53I3 | ENSP00000301585 | ENSP00000238721 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) | 0.922 |
ICT1 | UBC | ENSP00000301585 | ENSP00000344818 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | ubiquitin C | 0.532 |
IKZF3 | UBC | ENSP00000344544 | ENSP00000344818 | IKAROS family zinc finger 3 (Aiolos) | ubiquitin C | 0.816 |
ILF2 | ICT1 | ENSP00000355011 | ENSP00000301585 | interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | 0.607 |
ILF2 | MRPL23 | ENSP00000355011 | ENSP00000370930 | interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus | mitochondrial ribosomal protein L23 | 0.613 |
ILF2 | MRPL28 | ENSP00000355011 | ENSP00000199706 | interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus | mitochondrial ribosomal protein L28 | 0.644 |
ILF2 | UBC | ENSP00000355011 | ENSP00000344818 | interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus | ubiquitin C | 0.992 |
MRPL23 | ICT1 | ENSP00000370930 | ENSP00000301585 | mitochondrial ribosomal protein L23 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | 0.951 |
MRPL23 | ILF2 | ENSP00000370930 | ENSP00000355011 | mitochondrial ribosomal protein L23 | interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus | 0.613 |