node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHSP | HBA1 | ENSP00000307199 | ENSP00000322421 | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity) | 0.973 |
AHSP | HBA2 | ENSP00000307199 | ENSP00000251595 | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | hemoglobin, alpha 2 | 0.996 |
AHSP | HBB | ENSP00000307199 | ENSP00000333994 | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | hemoglobin, beta | 0.951 |
AHSP | HBE1 | ENSP00000307199 | ENSP00000292896 | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | hemoglobin, epsilon 1; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin | 0.907 |
AHSP | HBQ1 | ENSP00000307199 | ENSP00000199708 | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | hemoglobin, theta 1 | 0.771 |
AHSP | HBZ | ENSP00000307199 | ENSP00000252951 | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | hemoglobin, zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac | 0.748 |
ALDH1A3 | EHHADH | ENSP00000332256 | ENSP00000231887 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.487 |
ALDH1A3 | HADHA | ENSP00000332256 | ENSP00000370023 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit | 0.482 |
ALDH1L1 | EHHADH | ENSP00000377083 | ENSP00000231887 | aldehyde dehydrogenase 1 family, member L1 | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.496 |
ALDH1L1 | HADHA | ENSP00000377083 | ENSP00000370023 | aldehyde dehydrogenase 1 family, member L1 | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit | 0.500 |
ALDH2 | EHHADH | ENSP00000261733 | ENSP00000231887 | aldehyde dehydrogenase 2 family (mitochondrial) | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.552 |
ALDH2 | HADHA | ENSP00000261733 | ENSP00000370023 | aldehyde dehydrogenase 2 family (mitochondrial) | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit | 0.520 |
ALDH3B2 | EHHADH | ENSP00000255084 | ENSP00000231887 | aldehyde dehydrogenase 3 family, member B2 | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.482 |
ALDH3B2 | HADHA | ENSP00000255084 | ENSP00000370023 | aldehyde dehydrogenase 3 family, member B2 | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit | 0.482 |
ALDH7A1 | EHHADH | ENSP00000387123 | ENSP00000231887 | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.947 |
ALDH7A1 | HADHA | ENSP00000387123 | ENSP00000370023 | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit | 0.520 |
ALDH8A1 | EHHADH | ENSP00000265605 | ENSP00000231887 | aldehyde dehydrogenase 8 family, member A1; Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro) | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.494 |
ALDH8A1 | HADHA | ENSP00000265605 | ENSP00000370023 | aldehyde dehydrogenase 8 family, member A1; Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro) | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit | 0.482 |
AUH | EHHADH | ENSP00000364883 | ENSP00000231887 | AU RNA binding protein/enoyl-CoA hydratase; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.539 |
AUH | HADHA | ENSP00000364883 | ENSP00000370023 | AU RNA binding protein/enoyl-CoA hydratase; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit | 0.575 |