Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
MPP7 MPP7 MPP2 MPP2 ACAN ACAN CARD10 CARD10 DLG1 DLG1 CLEC12A CLEC12A DLG2 DLG2 DLG3 DLG3 CLEC2D CLEC2D CASK CASK SVEP1 SVEP1 DLG4 DLG4 CARD14 CARD14 MPP4 MPP4 MPP6 MPP6 LGI1 LGI1 MPP5 MPP5 LRGUK LRGUK TAZ TAZ ADAM11 ADAM11 MPP3 MPP3 MPP1 MPP1 LGI2 LGI2 GAS7 GAS7 CLEC5A CLEC5A LGI4 LGI4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ADAM11ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (769 aa)
MPP6membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) (540 aa)
CARD10caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK (1032 aa)
CLEC2DC-type lectin domain family 2, member D; Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans (194 aa)
MPP5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) (675 aa)
MPP2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (552 aa)
LRGUKleucine-rich repeats and guanylate kinase domain containing (825 aa)
DLG4discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) (767 aa)
TAZtafazzin (292 aa)
LGI4leucine-rich repeat LGI family, member 4 (537 aa)
MPP7membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7); Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (576 aa)
CARD14caspase recruitment domain family, member 14; Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 (1004 aa)
DLG1discs, large homolog 1 (Drosophila) (926 aa)
CLEC12AC-type lectin domain family 12, member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases (275 aa)
MPP1membrane protein, palmitoylated 1, 55kDa; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity) (466 aa)
LGI1leucine-rich, glioma inactivated 1; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival (557 aa)
DLG3discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (817 aa)
DLG2discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) (975 aa)
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family) (921 aa)
LGI2leucine-rich repeat LGI family, member 2 (545 aa)
MPP3membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) (585 aa)
SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (3571 aa)
MPP4membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4); May play a role in retinal photoreceptors development (By similarity) (637 aa)
ACANaggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region (2530 aa)
GAS7growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons (476 aa)
CLEC5AC-type lectin domain family 5, member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release (188 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (30%)