node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | UBC | ENSP00000448165 | ENSP00000344818 | apoptotic peptidase activating factor 1 | ubiquitin C | 0.755 |
SLC24A6 | UBC | ENSP00000202831 | ENSP00000344818 | solute carrier family 24 (sodium/lithium/calcium exchanger), member 6; Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin secretion in pancreatic beta- cells during the first phase of insulin secretion- acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. I [...] | ubiquitin C | 0.509 |
SLC9A1 | SLC9B1 | ENSP00000263980 | ENSP00000296422 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction | solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 | 0.637 |
SLC9A1 | SLC9B2 | ENSP00000263980 | ENSP00000354574 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction | solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity) | 0.736 |
SLC9A1 | SLC9C1 | ENSP00000263980 | ENSP00000306627 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction | solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1; Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity) | 0.900 |
SLC9A1 | UBC | ENSP00000263980 | ENSP00000344818 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction | ubiquitin C | 0.739 |
SLC9A2 | SLC9B1 | ENSP00000233969 | ENSP00000296422 | solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption | solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 | 0.492 |
SLC9A2 | SLC9B2 | ENSP00000233969 | ENSP00000354574 | solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption | solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity) | 0.794 |
SLC9A2 | SLC9C1 | ENSP00000233969 | ENSP00000306627 | solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption | solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1; Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity) | 0.536 |
SLC9A3 | SLC9B1 | ENSP00000264938 | ENSP00000296422 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction | solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 | 0.505 |
SLC9A3 | UBC | ENSP00000264938 | ENSP00000344818 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction | ubiquitin C | 0.819 |
SLC9A4 | SLC9B1 | ENSP00000295269 | ENSP00000296422 | solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of [...] | solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 | 0.418 |
SLC9A4 | SLC9B2 | ENSP00000295269 | ENSP00000354574 | solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of [...] | solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity) | 0.420 |
SLC9A4 | SLC9C1 | ENSP00000295269 | ENSP00000306627 | solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of [...] | solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1; Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity) | 0.485 |
SLC9A5 | SLC9B1 | ENSP00000299798 | ENSP00000296422 | solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity) | solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 | 0.589 |
SLC9A5 | SLC9B2 | ENSP00000299798 | ENSP00000354574 | solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity) | solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity) | 0.836 |
SLC9A5 | SLC9C1 | ENSP00000299798 | ENSP00000306627 | solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity) | solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1; Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity) | 0.566 |
SLC9A7 | SLC9B1 | ENSP00000330320 | ENSP00000296422 | solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis | solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 | 0.709 |
SLC9A7 | SLC9B2 | ENSP00000330320 | ENSP00000354574 | solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis | solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity) | 0.834 |
SLC9A8 | SLC9B1 | ENSP00000354966 | ENSP00000296422 | solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction | solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 | 0.652 |