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LRBA LRBA HSPB8 HSPB8 BAG2 BAG2 KIF15 KIF15 HSPA6 HSPA6 RPP30 RPP30 INPPL1 INPPL1 POP1 POP1 HSP90AA1 HSP90AA1 SRP72 SRP72 GPRASP2 GPRASP2 USP19 USP19 MLF2 MLF2 BRD4 BRD4 UBC UBC HDAC11 HDAC11 GCN1L1 GCN1L1 JMJD6 JMJD6 PRKAA2 PRKAA2 RGS20 RGS20 FAM96B FAM96B CALU CALU MMS19 MMS19 PMVK PMVK FAM96A FAM96A SOX2 SOX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MLF2myeloid leukemia factor 2 (248 aa)
BRD4bromodomain containing 4; Plays a role in a process governing chromosomal dynamics during mitosis (By similarity) (1362 aa)
HSPB8heat shock 22kDa protein 8; Displays temperature-dependent chaperone activity (196 aa)
HDAC11histone deacetylase 11; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (347 aa)
RGS20regulator of G-protein signaling 20; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity) (388 aa)
INPPL1inositol polyphosphate phosphatase-like 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 traf [...] (1258 aa)
FAM96Afamily with sequence similarity 96, member A; May play a role in chromosome segregation through establishment of sister chromatid cohesion (By similarity) (160 aa)
GCN1L1GCN1 general control of amino-acid synthesis 1-like 1 (yeast) (2671 aa)
HSPA6heat shock 70kDa protein 6 (HSP70B’); In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity) (643 aa)
SOX2SRY (sex determining region Y)-box 2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiat [...] (317 aa)
KIF15kinesin family member 15; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly (By similarity) (1388 aa)
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (854 aa)
GPRASP2G protein-coupled receptor associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors (838 aa)
POP1processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae); Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP (1024 aa)
SRP72signal recognition particle 72kDa; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (671 aa)
UBCubiquitin C (685 aa)
LRBALPS-responsive vesicle trafficking, beach and anchor containing; May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity) (2863 aa)
PMVKphosphomevalonate kinase (192 aa)
BAG2BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (211 aa)
MMS19MMS19 nucleotide excision repair homolog (S. cerevisiae) (1030 aa)
PRKAA2protein kinase, AMP-activated, alpha 2 catalytic subunit; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as [...] (552 aa)
FAM96Bfamily with sequence similarity 96, member B; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (163 aa)
RPP30ribonuclease P/MRP 30kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (322 aa)
JMJD6jumonji domain containing 6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates [...] (414 aa)
USP19ubiquitin specific peptidase 19 (1419 aa)
CALUcalumenin (323 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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