Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
ENSG00000267748 ENSG00000267748 TENM2 TENM2 LCN15 LCN15 SPINT1 SPINT1 TFPI TFPI VWCE VWCE ENSG00000179066 ENSG00000179066 WFDC6 WFDC6 TFPI2 TFPI2 WFDC8 WFDC8 TPSD1 TPSD1 FRAS1 FRAS1 OTOGL OTOGL SPINT4 SPINT4 AMBP AMBP EPPIN EPPIN SPINT2 SPINT2 SPINT3 SPINT3 MUC5AC MUC5AC ENSG00000249139 ENSG00000249139 MUC2 MUC2 PTK7 PTK7 MUC6 MUC6 TECTA TECTA PAPLN PAPLN MUC5B MUC5B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
TPSD1tryptase delta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity) (242 aa)
SPINT3serine peptidase inhibitor, Kunitz type, 3 (89 aa)
TFPI2tissue factor pathway inhibitor 2; May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin (235 aa)
PTK7PTK7 protein tyrosine kinase 7 (1070 aa)
TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor); Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (304 aa)
TECTAtectorin alpha; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals (2155 aa)
FRAS1Fraser syndrome 1 (4012 aa)
AMBPalpha-1-microglobulin/bikunin precursor; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization (352 aa)
SPINT4serine peptidase inhibitor, Kunitz type 4 (99 aa)
WFDC8WAP four-disulfide core domain 8 (241 aa)
SPINT2serine peptidase inhibitor, Kunitz type, 2; Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa (252 aa)
LCN15lipocalin 15 (184 aa)
ENSG00000179066Uncharacterized protein (148 aa)
VWCEvon Willebrand factor C and EGF domains; May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma (955 aa)
SPINT1serine peptidase inhibitor, Kunitz type 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) (529 aa)
PAPLNpapilin, proteoglycan-like sulfated glycoprotein (1251 aa)
WFDC6WAP four-disulfide core domain 6 (86 aa)
OTOGLotogelin-like (2344 aa)
MUC6mucin 6, oligomeric mucus/gel-forming; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis (2439 aa)
MUC2mucin 2, oligomeric mucus/gel-forming; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer (2817 aa)
ENSG00000249139EPPIN-WFDC6 readthrough (179 aa)
TENM2teneurin transmembrane protein 2; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer (2774 aa)
MUC5ACmucin 5AC, oligomeric mucus/gel-forming (623 aa)
MUC5Bmucin 5B, oligomeric mucus/gel-forming (5762 aa)
EPPINepididymal peptidase inhibitor; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (179 aa)
ENSG00000267748Protein C19orf33 (158 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (31%)