node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCC1 | TCN2 | ENSP00000382342 | ENSP00000215838 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | transcobalamin II; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells | 0.914 |
CBL | CD320 | ENSP00000264033 | ENSP00000301458 | Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...] | CD320 molecule; Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin | 0.450 |
CBL | TCN2 | ENSP00000264033 | ENSP00000215838 | Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...] | transcobalamin II; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells | 0.849 |
CD320 | CBL | ENSP00000301458 | ENSP00000264033 | CD320 molecule; Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin | Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...] | 0.450 |
CD320 | TCN2 | ENSP00000301458 | ENSP00000215838 | CD320 molecule; Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin | transcobalamin II; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells | 0.975 |
TCN2 | ABCC1 | ENSP00000215838 | ENSP00000382342 | transcobalamin II; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 0.914 |
TCN2 | CBL | ENSP00000215838 | ENSP00000264033 | transcobalamin II; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells | Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...] | 0.849 |
TCN2 | CD320 | ENSP00000215838 | ENSP00000301458 | transcobalamin II; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells | CD320 molecule; Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin | 0.975 |