node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | IKBKG | ENSP00000275493 | ENSP00000358622 | epidermal growth factor receptor | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either ’Lys-63’- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Als [...] | 0.598 |
EGFR | LGALS2 | ENSP00000275493 | ENSP00000215886 | epidermal growth factor receptor | lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known | 0.574 |
EGFR | LGALS3 | ENSP00000275493 | ENSP00000254301 | epidermal growth factor receptor | lectin, galactoside-binding, soluble, 3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus- acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells | 0.913 |
EGFR | TUBA1A | ENSP00000275493 | ENSP00000301071 | epidermal growth factor receptor | tubulin, alpha 1a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.827 |
EGFR | TUBA4A | ENSP00000275493 | ENSP00000248437 | epidermal growth factor receptor | tubulin, alpha 4a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.683 |
IKBKG | EGFR | ENSP00000358622 | ENSP00000275493 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either ’Lys-63’- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Als [...] | epidermal growth factor receptor | 0.598 |
IKBKG | LTA | ENSP00000358622 | ENSP00000403495 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either ’Lys-63’- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Als [...] | lymphotoxin alpha (TNF superfamily, member 1); Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo | 0.416 |
LGALS2 | EGFR | ENSP00000215886 | ENSP00000275493 | lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known | epidermal growth factor receptor | 0.574 |
LGALS2 | LGALS3 | ENSP00000215886 | ENSP00000254301 | lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known | lectin, galactoside-binding, soluble, 3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus- acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells | 0.549 |
LGALS2 | LTA | ENSP00000215886 | ENSP00000403495 | lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known | lymphotoxin alpha (TNF superfamily, member 1); Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo | 0.585 |
LGALS2 | TNFSF15 | ENSP00000215886 | ENSP00000363157 | lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known | tumor necrosis factor (ligand) superfamily, member 15; Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis | 0.573 |
LGALS2 | TUBA1A | ENSP00000215886 | ENSP00000301071 | lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known | tubulin, alpha 1a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.573 |
LGALS2 | TUBA1B | ENSP00000215886 | ENSP00000336799 | lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known | tubulin, alpha 1b; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.573 |
LGALS2 | TUBA4A | ENSP00000215886 | ENSP00000248437 | lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known | tubulin, alpha 4a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.582 |
LGALS3 | EGFR | ENSP00000254301 | ENSP00000275493 | lectin, galactoside-binding, soluble, 3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus- acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells | epidermal growth factor receptor | 0.913 |
LGALS3 | LGALS2 | ENSP00000254301 | ENSP00000215886 | lectin, galactoside-binding, soluble, 3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus- acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells | lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known | 0.549 |
LTA | IKBKG | ENSP00000403495 | ENSP00000358622 | lymphotoxin alpha (TNF superfamily, member 1); Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either ’Lys-63’- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Als [...] | 0.416 |
LTA | LGALS2 | ENSP00000403495 | ENSP00000215886 | lymphotoxin alpha (TNF superfamily, member 1); Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo | lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known | 0.585 |
LTA | TUBA1A | ENSP00000403495 | ENSP00000301071 | lymphotoxin alpha (TNF superfamily, member 1); Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo | tubulin, alpha 1a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.573 |
LTA | TUBA1B | ENSP00000403495 | ENSP00000336799 | lymphotoxin alpha (TNF superfamily, member 1); Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo | tubulin, alpha 1b; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.573 |