node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIDA | FAM118A | ENSP00000339161 | ENSP00000216214 | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | family with sequence similarity 118, member A | 0.601 |
ATOX1 | FAM118A | ENSP00000316854 | ENSP00000216214 | ATX1 antioxidant protein 1 homolog (yeast); Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense | family with sequence similarity 118, member A | 0.534 |
ATOX1 | UBC | ENSP00000316854 | ENSP00000344818 | ATX1 antioxidant protein 1 homolog (yeast); Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense | ubiquitin C | 0.721 |
BAG3 | UBC | ENSP00000358081 | ENSP00000344818 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | ubiquitin C | 0.972 |
FAM118A | AIDA | ENSP00000216214 | ENSP00000339161 | family with sequence similarity 118, member A | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | 0.601 |
FAM118A | ATOX1 | ENSP00000216214 | ENSP00000316854 | family with sequence similarity 118, member A | ATX1 antioxidant protein 1 homolog (yeast); Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense | 0.534 |
FAM118A | FAM118B | ENSP00000216214 | ENSP00000433343 | family with sequence similarity 118, member A | family with sequence similarity 118, member B | 0.717 |
FAM118A | MOB1A | ENSP00000216214 | ENSP00000379364 | family with sequence similarity 118, member A | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | 0.461 |
FAM118A | WDR4 | ENSP00000216214 | ENSP00000328671 | family with sequence similarity 118, member A | WD repeat domain 4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit | 0.534 |
FAM118A | ZNF451 | ENSP00000216214 | ENSP00000359740 | family with sequence similarity 118, member A | zinc finger protein 451; May be involved in transcriptional regulation. Coactivator for steroid receptors | 0.487 |
FAM118B | FAM118A | ENSP00000433343 | ENSP00000216214 | family with sequence similarity 118, member B | family with sequence similarity 118, member A | 0.717 |
FAM118B | UBC | ENSP00000433343 | ENSP00000344818 | family with sequence similarity 118, member B | ubiquitin C | 0.620 |
GLRX3 | UBC | ENSP00000330836 | ENSP00000344818 | glutaredoxin 3; Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity | ubiquitin C | 0.836 |
MOB1A | FAM118A | ENSP00000379364 | ENSP00000216214 | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | family with sequence similarity 118, member A | 0.461 |
MOB1A | UBC | ENSP00000379364 | ENSP00000344818 | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | ubiquitin C | 0.795 |
UBC | ATOX1 | ENSP00000344818 | ENSP00000316854 | ubiquitin C | ATX1 antioxidant protein 1 homolog (yeast); Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense | 0.721 |
UBC | BAG3 | ENSP00000344818 | ENSP00000358081 | ubiquitin C | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | 0.972 |
UBC | FAM118B | ENSP00000344818 | ENSP00000433343 | ubiquitin C | family with sequence similarity 118, member B | 0.620 |
UBC | GLRX3 | ENSP00000344818 | ENSP00000330836 | ubiquitin C | glutaredoxin 3; Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity | 0.836 |
UBC | MOB1A | ENSP00000344818 | ENSP00000379364 | ubiquitin C | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | 0.795 |