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FXN FXN ACAA2 ACAA2 ACAT1 ACAT1 AK3 AK3 SOD1 SOD1 ACO2 ACO2 MRPL33 MRPL33 CS CS MRPS2 MRPS2 MRPL17 MRPL17 ACLY ACLY MRPL32 MRPL32 MRPL22 MRPL22 IDH3A IDH3A MRPL27 MRPL27 MRPL16 MRPL16 IDH3B IDH3B MRPL41 MRPL41 UBC UBC MRPL13 MRPL13 SIN3A SIN3A MRPL40 MRPL40 MRPL19 MRPL19 MRPL43 MRPL43 TRIP12 TRIP12 XPNPEP3 XPNPEP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ACO2aconitase 2, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity) (780 aa)
MRPL32mitochondrial ribosomal protein L32 (188 aa)
MRPL27mitochondrial ribosomal protein L27 (148 aa)
MRPS2mitochondrial ribosomal protein S2 (296 aa)
ACLYATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
ACAT1acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism (427 aa)
SOD1superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) (154 aa)
TRIP12thyroid hormone receptor interactor 12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located [...] (1992 aa)
ACAA2acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage (397 aa)
MRPL17mitochondrial ribosomal protein L17 (175 aa)
MRPL33mitochondrial ribosomal protein L33 (65 aa)
IDH3Aisocitrate dehydrogenase 3 (NAD+) alpha (366 aa)
MRPL16mitochondrial ribosomal protein L16; Component of the large subunit of mitochondrial ribosome (251 aa)
MRPL13mitochondrial ribosomal protein L13 (178 aa)
MRPL40mitochondrial ribosomal protein L40 (206 aa)
MRPL43mitochondrial ribosomal protein L43 (235 aa)
CScitrate synthase (466 aa)
UBCubiquitin C (685 aa)
XPNPEP3X-prolyl aminopeptidase (aminopeptidase P) 3, putative (507 aa)
SIN3ASIN3 transcription regulator homolog A (yeast); Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation (1273 aa)
MRPL41mitochondrial ribosomal protein L41; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (137 aa)
FXNfrataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] (210 aa)
IDH3Bisocitrate dehydrogenase 3 (NAD+) beta (385 aa)
AK3adenylate kinase 3; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP-AMP phosphotransferase and ITP-AMP phosphotransferase activities (227 aa)
MRPL19mitochondrial ribosomal protein L19 (292 aa)
MRPL22mitochondrial ribosomal protein L22 (206 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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