node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DGCR8 | PLEK2 | ENSP00000263209 | ENSP00000216446 | DiGeorge syndrome critical region gene 8 | pleckstrin 2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation | 0.644 |
INPPL1 | PLEK2 | ENSP00000298229 | ENSP00000216446 | inositol polyphosphate phosphatase-like 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 traf [...] | pleckstrin 2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation | 0.644 |
INPPL1 | RPS19 | ENSP00000298229 | ENSP00000470004 | inositol polyphosphate phosphatase-like 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 traf [...] | ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits | 0.456 |
INPPL1 | UBC | ENSP00000298229 | ENSP00000344818 | inositol polyphosphate phosphatase-like 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 traf [...] | ubiquitin C | 0.933 |
PLEK2 | DGCR8 | ENSP00000216446 | ENSP00000263209 | pleckstrin 2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation | DiGeorge syndrome critical region gene 8 | 0.644 |
PLEK2 | INPPL1 | ENSP00000216446 | ENSP00000298229 | pleckstrin 2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation | inositol polyphosphate phosphatase-like 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 traf [...] | 0.644 |
PLEK2 | RPS19 | ENSP00000216446 | ENSP00000470004 | pleckstrin 2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation | ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits | 0.644 |
PLEK2 | UBC | ENSP00000216446 | ENSP00000344818 | pleckstrin 2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation | ubiquitin C | 0.483 |
RPS19 | INPPL1 | ENSP00000470004 | ENSP00000298229 | ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits | inositol polyphosphate phosphatase-like 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 traf [...] | 0.456 |
RPS19 | PLEK2 | ENSP00000470004 | ENSP00000216446 | ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits | pleckstrin 2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation | 0.644 |
RPS19 | UBC | ENSP00000470004 | ENSP00000344818 | ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits | ubiquitin C | 0.981 |
UBC | INPPL1 | ENSP00000344818 | ENSP00000298229 | ubiquitin C | inositol polyphosphate phosphatase-like 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 traf [...] | 0.933 |
UBC | PLEK2 | ENSP00000344818 | ENSP00000216446 | ubiquitin C | pleckstrin 2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation | 0.483 |
UBC | RPS19 | ENSP00000344818 | ENSP00000470004 | ubiquitin C | ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits | 0.981 |