node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C6orf132 | CHGA | ENSP00000341368 | ENSP00000216492 | chromosome 6 open reading frame 132 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | 0.576 |
CEBPA | CHGA | ENSP00000427514 | ENSP00000216492 | CCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | 0.803 |
CEBPA | UBC | ENSP00000427514 | ENSP00000344818 | CCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers | ubiquitin C | 0.987 |
CHGA | C6orf132 | ENSP00000216492 | ENSP00000341368 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | chromosome 6 open reading frame 132 | 0.576 |
CHGA | CEBPA | ENSP00000216492 | ENSP00000427514 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | CCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers | 0.803 |
CHGA | CHGB | ENSP00000216492 | ENSP00000368244 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | chromogranin B (secretogranin 1); Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | 0.897 |
CHGA | PLG | ENSP00000216492 | ENSP00000308938 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.716 |
CHGA | SCG3 | ENSP00000216492 | ENSP00000220478 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | secretogranin III | 0.977 |
CHGA | STX1A | ENSP00000216492 | ENSP00000222812 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | syntaxin 1A (brain) | 0.410 |
CHGA | STX1B | ENSP00000216492 | ENSP00000215095 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | syntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity) | 0.412 |
CHGA | STX2 | ENSP00000216492 | ENSP00000376178 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | syntaxin 2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm | 0.411 |
CHGA | SYT1 | ENSP00000216492 | ENSP00000261205 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | 0.680 |
CHGA | TRIB3 | ENSP00000216492 | ENSP00000217233 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | tribbles homolog 3 (Drosophila); Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the ’Thr-308’ phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display k [...] | 0.582 |
CHGB | CHGA | ENSP00000368244 | ENSP00000216492 | chromogranin B (secretogranin 1); Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | 0.897 |
CHGB | SCG3 | ENSP00000368244 | ENSP00000220478 | chromogranin B (secretogranin 1); Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | secretogranin III | 0.700 |
CHGB | STX1B | ENSP00000368244 | ENSP00000215095 | chromogranin B (secretogranin 1); Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | syntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity) | 0.414 |
CHGB | SYT1 | ENSP00000368244 | ENSP00000261205 | chromogranin B (secretogranin 1); Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | 0.701 |
NEK2 | UBC | ENSP00000355966 | ENSP00000344818 | NIMA-related kinase 2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex [...] | ubiquitin C | 0.986 |
PARK2 | UBC | ENSP00000355865 | ENSP00000344818 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | ubiquitin C | 0.999 |
PLG | CHGA | ENSP00000308938 | ENSP00000216492 | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | 0.716 |