Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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 | PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) (640 aa) | ||
 | ENO2 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) (434 aa) | ||
 | LDHB | lactate dehydrogenase B (334 aa) | ||
 | HSPE1 | heat shock 10kDa protein 1 (chaperonin 10); Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (102 aa) | ||
 | ENO1 | enolase 1, (alpha) (434 aa) | ||
 | L2HGDH | L-2-hydroxyglutarate dehydrogenase (463 aa) | ||
 | AKT1 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] (480 aa) | ||
 | PRCC | papillary renal cell carcinoma (translocation-associated); May regulate cell cycle progression through interaction with MAD2L2 (491 aa) | ||
 | LDHC | lactate dehydrogenase C; Possible role in sperm motility (332 aa) | ||
 | LDHAL6A | lactate dehydrogenase A-like 6A; Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed (332 aa) | ||
 | LDHAL6B | lactate dehydrogenase A-like 6B (381 aa) | ||
 | ZNHIT2 | zinc finger, HIT-type containing 2 (403 aa) | ||
 | NCOA1 | nuclear receptor coactivator 1 (1441 aa) | ||
 | ME2 | malic enzyme 2, NAD(+)-dependent, mitochondrial (584 aa) | ||
 | ENO3 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration (434 aa) | ||
 | MDH2 | malate dehydrogenase 2, NAD (mitochondrial) (338 aa) | ||
 | HSPD1 | heat shock 60kDa protein 1 (chaperonin); Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (573 aa) | ||
 | UBE2L3 | ubiquitin-conjugating enzyme E2L 3; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine- in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys-11’-linked polyubiquitination. Involved in th [...] (154 aa) | ||
 | ENO4 | enolase family member 4 (628 aa) | ||
 | ME3 | malic enzyme 3, NADP(+)-dependent, mitochondrial (604 aa) | ||
 | ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic (572 aa) | ||
 | MDH1B | malate dehydrogenase 1B, NAD (soluble) (518 aa) | ||
 | UEVLD | UEV and lactate/malate dehyrogenase domains; Possible negative regulator of polyubiquitination (471 aa) | ||
 | PPIA | peptidylprolyl isomerase A (cyclophilin A); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) (165 aa) | ||
 | MDH1 | malate dehydrogenase 1, NAD (soluble) (352 aa) | ||
 | LDHA | lactate dehydrogenase A (361 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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