Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | MRPL28 | mitochondrial ribosomal protein L28 (256 aa) | ||
 | XYLB | xylulokinase homolog (H. influenzae); Phosphorylates D-xylulose to produce D-xylulose 5- phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis (536 aa) | ||
 | ADH1A | alcohol dehydrogenase 1A (class I), alpha polypeptide (375 aa) | ||
 | APMAP | adipocyte plasma membrane associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation (416 aa) | ||
 | DHDH | dihydrodiol dehydrogenase (dimeric) (334 aa) | ||
 | CANX | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] (592 aa) | ||
 | DHRS11 | dehydrogenase/reductase (SDR family) member 11 (260 aa) | ||
 | AGPS | alkylglycerone phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids (By similarity) (658 aa) | ||
 | HIBADH | 3-hydroxyisobutyrate dehydrogenase (336 aa) | ||
 | ADH4 | alcohol dehydrogenase 4 (class II), pi polypeptide (380 aa) | ||
 | GFOD2 | glucose-fructose oxidoreductase domain containing 2; Promotes matrix assembly (By similarity) (385 aa) | ||
 | HNRPDL | heterogeneous nuclear ribonucleoprotein D-like; Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3’-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or [...] (420 aa) | ||
 | ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (374 aa) | ||
 | LDHD | lactate dehydrogenase D (507 aa) | ||
 | ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide (375 aa) | ||
 | D2HGDH | D-2-hydroxyglutarate dehydrogenase; Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate (521 aa) | ||
 | CHDH | choline dehydrogenase (594 aa) | ||
 | GLYR1 | glyoxylate reductase 1 homolog (Arabidopsis) (553 aa) | ||
 | CLGN | calmegin; Probably plays an important role in spermatogenesis. Binds calcium ions (610 aa) | ||
 | CNDP1 | carnosine dipeptidase 1 (metallopeptidase M20 family) (507 aa) | ||
 | DHCR24 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis (516 aa) | ||
 | IDNK | idnK, gluconokinase homolog (E. coli) (187 aa) | ||
 | GFOD1 | glucose-fructose oxidoreductase domain containing 1 (390 aa) | ||
 | ADH6 | alcohol dehydrogenase 6 (class V) (375 aa) | ||
 | ADH7 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism (394 aa) | ||
 | ETFA | electron-transfer-flavoprotein, alpha polypeptide; The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (333 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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