node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARRB1 | GNAI1 | ENSP00000409581 | ENSP00000343027 | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.444 |
ARRB1 | GPR50 | ENSP00000409581 | ENSP00000218316 | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | G protein-coupled receptor 50; Does not bind melatonin | 0.743 |
ARRB1 | MT1A | ENSP00000409581 | ENSP00000290705 | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids | 0.570 |
CARHSP1 | LIN28A | ENSP00000311847 | ENSP00000254231 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | lin-28 homolog A (C. elegans); Acts as a ’translational enhancer’, driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) [...] | 0.441 |
CARHSP1 | LIN28B | ENSP00000311847 | ENSP00000344401 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | lin-28 homolog B (C. elegans); Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5’-GGAG-3’ motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5’-GGAG-3’ motif in the terminal loop, leading to their terminal uridylation [...] | 0.441 |
CSDC2 | YBX1 | ENSP00000302485 | ENSP00000361626 | cold shock domain containing C2, RNA binding; RNA-binding factor which binds specifically to the very 3’-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity) | Y box binding protein 1; Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at ’Lys-6’ and ’Lys-7’. Binds to promoters that contain a Y-box (5’-CTGATTGGCCAA-3’), such as MD [...] | 0.817 |
GNAI1 | ARRB1 | ENSP00000343027 | ENSP00000409581 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | 0.444 |
GNAI1 | GPR50 | ENSP00000343027 | ENSP00000218316 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | G protein-coupled receptor 50; Does not bind melatonin | 0.626 |
GNAI1 | MT1A | ENSP00000343027 | ENSP00000290705 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids | 0.570 |
GNAI1 | MTNR1A | ENSP00000343027 | ENSP00000302811 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | melatonin receptor 1A; High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity | 0.937 |
GNAI1 | MTNR1B | ENSP00000343027 | ENSP00000257068 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | melatonin receptor 1B; High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity | 0.937 |
GPR50 | ARRB1 | ENSP00000218316 | ENSP00000409581 | G protein-coupled receptor 50; Does not bind melatonin | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | 0.743 |
GPR50 | GNAI1 | ENSP00000218316 | ENSP00000343027 | G protein-coupled receptor 50; Does not bind melatonin | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.626 |
GPR50 | MT1A | ENSP00000218316 | ENSP00000290705 | G protein-coupled receptor 50; Does not bind melatonin | metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids | 0.622 |
GPR50 | MT2A | ENSP00000218316 | ENSP00000245185 | G protein-coupled receptor 50; Does not bind melatonin | metallothionein 2A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids | 0.622 |
GPR50 | MTNR1A | ENSP00000218316 | ENSP00000302811 | G protein-coupled receptor 50; Does not bind melatonin | melatonin receptor 1A; High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity | 0.589 |
GPR50 | MTNR1B | ENSP00000218316 | ENSP00000257068 | G protein-coupled receptor 50; Does not bind melatonin | melatonin receptor 1B; High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity | 0.592 |
GPR50 | ZNF572 | ENSP00000218316 | ENSP00000319305 | G protein-coupled receptor 50; Does not bind melatonin | zinc finger protein 572; May be involved in transcriptional regulation (By similarity) | 0.537 |
LIN28A | CARHSP1 | ENSP00000254231 | ENSP00000311847 | lin-28 homolog A (C. elegans); Acts as a ’translational enhancer’, driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) [...] | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | 0.441 |
LIN28B | CARHSP1 | ENSP00000344401 | ENSP00000311847 | lin-28 homolog B (C. elegans); Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5’-GGAG-3’ motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5’-GGAG-3’ motif in the terminal loop, leading to their terminal uridylation [...] | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | 0.441 |