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NLGN3 NLGN3 NLGN1 NLGN1 NLGN4Y NLGN4Y ITIH6 ITIH6 CES1 CES1 CES3 CES3 ACHE ACHE CES2 CES2 NLGN4X NLGN4X CES4A CES4A CES5A CES5A TG TG SLMAP SLMAP BCHE BCHE NLGN2 NLGN2 CEL CEL GMPS GMPS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ITIH6inter-alpha-trypsin inhibitor heavy chain family, member 6 (1313 aa)
TGthyroglobulin (2768 aa)
BCHEbutyrylcholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (602 aa)
NLGN4Xneuroligin 4, X-linked; Putative neuronal cell surface protein involved in cell- cell-interactions (816 aa)
SLMAPsarcolemma associated protein (811 aa)
ACHEacetylcholinesterase (617 aa)
CES3carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics (571 aa)
NLGN2neuroligin 2; Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of sign [...] (835 aa)
CES2carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (623 aa)
NLGN4Yneuroligin 4, Y-linked; Putative neuronal cell surface protein involved in cell- cell-interactions (816 aa)
NLGN3neuroligin 3 (848 aa)
CES1carboxylesterase 1; Has no esterase activity (Probable) (568 aa)
NLGN1neuroligin 1; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses (By similarity) (823 aa)
CELcarboxyl ester lipase (bile salt-stimulated lipase); Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides (756 aa)
GMPSguanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division (693 aa)
CES5Acarboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) (604 aa)
CES4Acarboxylesterase 4A; Probable carboxylesterase (By similarity) (468 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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