node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CES1 | CES2 | ENSP00000353720 | ENSP00000317842 | carboxylesterase 1; Has no esterase activity (Probable) | carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine | 0.959 |
CES1 | CES3 | ENSP00000353720 | ENSP00000304782 | carboxylesterase 1; Has no esterase activity (Probable) | carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics | 0.910 |
CES1 | CES4A | ENSP00000353720 | ENSP00000444052 | carboxylesterase 1; Has no esterase activity (Probable) | carboxylesterase 4A; Probable carboxylesterase (By similarity) | 0.908 |
CES1 | CES5A | ENSP00000353720 | ENSP00000428864 | carboxylesterase 1; Has no esterase activity (Probable) | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | 0.908 |
CES2 | CES1 | ENSP00000317842 | ENSP00000353720 | carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine | carboxylesterase 1; Has no esterase activity (Probable) | 0.959 |
CES2 | CES3 | ENSP00000317842 | ENSP00000304782 | carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine | carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics | 0.909 |
CES2 | CES4A | ENSP00000317842 | ENSP00000444052 | carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine | carboxylesterase 4A; Probable carboxylesterase (By similarity) | 0.908 |
CES2 | CES5A | ENSP00000317842 | ENSP00000428864 | carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | 0.906 |
CES3 | CES1 | ENSP00000304782 | ENSP00000353720 | carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics | carboxylesterase 1; Has no esterase activity (Probable) | 0.910 |
CES3 | CES2 | ENSP00000304782 | ENSP00000317842 | carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics | carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine | 0.909 |
CES3 | CES4A | ENSP00000304782 | ENSP00000444052 | carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics | carboxylesterase 4A; Probable carboxylesterase (By similarity) | 0.911 |
CES3 | CES5A | ENSP00000304782 | ENSP00000428864 | carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | 0.908 |
CES4A | CES1 | ENSP00000444052 | ENSP00000353720 | carboxylesterase 4A; Probable carboxylesterase (By similarity) | carboxylesterase 1; Has no esterase activity (Probable) | 0.908 |
CES4A | CES2 | ENSP00000444052 | ENSP00000317842 | carboxylesterase 4A; Probable carboxylesterase (By similarity) | carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine | 0.908 |
CES4A | CES3 | ENSP00000444052 | ENSP00000304782 | carboxylesterase 4A; Probable carboxylesterase (By similarity) | carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics | 0.911 |
CES4A | CES5A | ENSP00000444052 | ENSP00000428864 | carboxylesterase 4A; Probable carboxylesterase (By similarity) | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | 0.911 |
CES5A | CES1 | ENSP00000428864 | ENSP00000353720 | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | carboxylesterase 1; Has no esterase activity (Probable) | 0.908 |
CES5A | CES2 | ENSP00000428864 | ENSP00000317842 | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine | 0.906 |
CES5A | CES3 | ENSP00000428864 | ENSP00000304782 | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics | 0.908 |
CES5A | CES4A | ENSP00000428864 | ENSP00000444052 | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | carboxylesterase 4A; Probable carboxylesterase (By similarity) | 0.911 |