node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATXN1 | UBC | ENSP00000244769 | ENSP00000344818 | ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function | ubiquitin C | 0.596 |
ENSG00000257529 | RPS3A | ENSP00000386655 | ENSP00000346050 | Uncharacterized protein | ribosomal protein S3A; May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity) | 0.985 |
ENSG00000257529 | SETD6 | ENSP00000386655 | ENSP00000219315 | Uncharacterized protein | SET domain containing 6; Protein-lysine N-methyltransferase that specifically monomethylates ’Lys-310’ of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity | 0.519 |
ENSG00000257529 | UBC | ENSP00000386655 | ENSP00000344818 | Uncharacterized protein | ubiquitin C | 0.479 |
FBXO18 | RAD52 | ENSP00000369335 | ENSP00000351284 | F-box protein, helicase, 18 | RAD52 homolog (S. cerevisiae); Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase | 0.924 |
FBXO18 | UBC | ENSP00000369335 | ENSP00000344818 | F-box protein, helicase, 18 | ubiquitin C | 0.930 |
KPNB1 | UBC | ENSP00000290158 | ENSP00000344818 | karyopherin (importin) beta 1; Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleopl [...] | ubiquitin C | 0.996 |
RAD52 | FBXO18 | ENSP00000351284 | ENSP00000369335 | RAD52 homolog (S. cerevisiae); Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase | F-box protein, helicase, 18 | 0.924 |
RELA | SETD6 | ENSP00000384273 | ENSP00000219315 | v-rel reticuloendotheliosis viral oncogene homolog A (avian); NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most a [...] | SET domain containing 6; Protein-lysine N-methyltransferase that specifically monomethylates ’Lys-310’ of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity | 0.970 |
RELA | UBC | ENSP00000384273 | ENSP00000344818 | v-rel reticuloendotheliosis viral oncogene homolog A (avian); NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most a [...] | ubiquitin C | 0.999 |
RPL36A | RPS3A | ENSP00000404375 | ENSP00000346050 | ribosomal protein L36a | ribosomal protein S3A; May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity) | 0.988 |
RPL36A | SETD6 | ENSP00000404375 | ENSP00000219315 | ribosomal protein L36a | SET domain containing 6; Protein-lysine N-methyltransferase that specifically monomethylates ’Lys-310’ of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity | 0.544 |
RPL36A | UBC | ENSP00000404375 | ENSP00000344818 | ribosomal protein L36a | ubiquitin C | 0.495 |
RPL36AL | RPS3A | ENSP00000346012 | ENSP00000346050 | ribosomal protein L36a-like | ribosomal protein S3A; May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity) | 0.987 |
RPL36AL | SETD6 | ENSP00000346012 | ENSP00000219315 | ribosomal protein L36a-like | SET domain containing 6; Protein-lysine N-methyltransferase that specifically monomethylates ’Lys-310’ of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity | 0.519 |
RPL36AL | UBC | ENSP00000346012 | ENSP00000344818 | ribosomal protein L36a-like | ubiquitin C | 0.799 |
RPS3A | ENSG00000257529 | ENSP00000346050 | ENSP00000386655 | ribosomal protein S3A; May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity) | Uncharacterized protein | 0.985 |
RPS3A | RPL36A | ENSP00000346050 | ENSP00000404375 | ribosomal protein S3A; May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity) | ribosomal protein L36a | 0.988 |
RPS3A | RPL36AL | ENSP00000346050 | ENSP00000346012 | ribosomal protein S3A; May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity) | ribosomal protein L36a-like | 0.987 |
RPS3A | UBC | ENSP00000346050 | ENSP00000344818 | ribosomal protein S3A; May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity) | ubiquitin C | 0.995 |