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TECR | trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids (308 aa) | |||
HSDL1 | hydroxysteroid dehydrogenase like 1 (330 aa) | |||
OAS3 | 2’-5’-oligoadenylate synthetase 3, 100kDa; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2’-5’- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in [...] (1087 aa) | |||
EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a re [...] (472 aa) | |||
EIF2S1 | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction [...] (315 aa) | |||
OASL | 2’-5’-oligoadenylate synthetase-like; Does not have 2’-5’-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L (514 aa) | |||
EIF2B2 | eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP (351 aa) | |||
EIF2B5 | eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP (721 aa) | |||
UBB | ubiquitin B (229 aa) | |||
ENSG00000173727 | Uncharacterized protein (112 aa) | |||
PITPNA | phosphatidylinositol transfer protein, alpha; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes (270 aa) | |||
IST1 | increased sodium tolerance 1 homolog (yeast); Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (360 aa) | |||
ZFAND4 | zinc finger, AN1-type domain 4 (727 aa) | |||
UBC | ubiquitin C (685 aa) | |||
EIF2B3 | eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP (452 aa) | |||
UBL4A | ubiquitin-like 4A; Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting (157 aa) | |||
EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a rea [...] (333 aa) | |||
UBD | ubiquitin D (165 aa) | |||
ISG15 | ISG15 ubiquitin-like modifier; Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic act [...] (165 aa) | |||
TECRL | trans-2,3-enoyl-CoA reductase-like (363 aa) | |||
EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP (543 aa) | |||
EIF2B1 | eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP (305 aa) | |||
FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (133 aa) | |||
EIF2S3L | Putative eukaryotic translation initiation factor 2 subunit 3-like protein ; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by wa [...] (472 aa) | |||
ENSG00000261750 | IST1 homolog (106 aa) | |||
UBBP4 | ubiquitin B pseudogene 4 (229 aa) |