Rho GTPase activating protein 17

Rho/Rac guanine nucleotide exchange factor (GEF) 18; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell [...]

Rho GTPase activating protein 17

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF)

Rho GTPase activating protein 17

FYVE, RhoGEF and PH domain containing 2; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate (By similarity)

Rho GTPase activating protein 17

FYVE, RhoGEF and PH domain containing 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity)

Rho GTPase activating protein 17

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Rho GTPase activating protein 17

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase

Rho GTPase activating protein 17

ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...]

Rho GTPase activating protein 17

Rho-related BTB domain containing 2

Rho GTPase activating protein 17

ras homolog family member D; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton (By similarity)

Rho GTPase activating protein 17

ras homolog family member Q; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia

Rho GTPase activating protein 17

ras homolog family member V; Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway (By similarity)

Rho GTPase activating protein 17

T-cell lymphoma invasion and metastasis 2; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by [...]

Rho GTPase activating protein 17

thyroid hormone receptor interactor 10

Rho GTPase activating protein 18; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

Rho/Rac guanine nucleotide exchange factor (GEF) 18; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell [...]

Rho GTPase activating protein 18; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF)

Rho GTPase activating protein 18; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

FYVE, RhoGEF and PH domain containing 2; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate (By similarity)

Rho GTPase activating protein 18; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

FYVE, RhoGEF and PH domain containing 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity)

Rho GTPase activating protein 18; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Rho GTPase activating protein 18; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase

Rho GTPase activating protein 18; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...]