node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CGA | CYP17A1 | ENSP00000358595 | ENSP00000358903 | glycoprotein hormones, alpha polypeptide | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | 0.905 |
CGA | LHB | ENSP00000358595 | ENSP00000221421 | glycoprotein hormones, alpha polypeptide | luteinizing hormone beta polypeptide; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids | 0.991 |
CGA | LHCGR | ENSP00000358595 | ENSP00000294954 | glycoprotein hormones, alpha polypeptide | luteinizing hormone/choriogonadotropin receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | 0.967 |
CGA | POMC | ENSP00000358595 | ENSP00000264708 | glycoprotein hormones, alpha polypeptide | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.936 |
CGA | SRD5A1 | ENSP00000358595 | ENSP00000274192 | glycoprotein hormones, alpha polypeptide | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology | 0.900 |
CGA | SRD5A3 | ENSP00000358595 | ENSP00000264228 | glycoprotein hormones, alpha polypeptide | steroid 5 alpha-reductase 3; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) | 0.900 |
CYP17A1 | CGA | ENSP00000358903 | ENSP00000358595 | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | glycoprotein hormones, alpha polypeptide | 0.905 |
CYP17A1 | LHB | ENSP00000358903 | ENSP00000221421 | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | luteinizing hormone beta polypeptide; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids | 0.932 |
CYP17A1 | LHCGR | ENSP00000358903 | ENSP00000294954 | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | luteinizing hormone/choriogonadotropin receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | 0.681 |
CYP17A1 | NR5A1 | ENSP00000358903 | ENSP00000362690 | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | nuclear receptor subfamily 5, group A, member 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5’-YCAAGGYC-3’ and 5’-RRAGGTCA-3’ are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional a [...] | 0.905 |
CYP17A1 | NR5A2 | ENSP00000358903 | ENSP00000356331 | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | nuclear receptor subfamily 5, group A, member 2; Binds to the sequence element 5’-AACGACCGACCTTGAG-3’ of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development | 0.840 |
CYP17A1 | POMC | ENSP00000358903 | ENSP00000264708 | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.994 |
CYP17A1 | SRD5A1 | ENSP00000358903 | ENSP00000274192 | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology | 0.962 |
CYP17A1 | SRD5A3 | ENSP00000358903 | ENSP00000264228 | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | steroid 5 alpha-reductase 3; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) | 0.928 |
GNAI2 | GNAS | ENSP00000312999 | ENSP00000360141 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase- they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division | GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) | 0.569 |
GNAI2 | LHB | ENSP00000312999 | ENSP00000221421 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase- they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division | luteinizing hormone beta polypeptide; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids | 0.576 |
GNAI2 | LHCGR | ENSP00000312999 | ENSP00000294954 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase- they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division | luteinizing hormone/choriogonadotropin receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | 0.644 |
GNAS | GNAI2 | ENSP00000360141 | ENSP00000312999 | GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase- they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division | 0.569 |
GNAS | LHB | ENSP00000360141 | ENSP00000221421 | GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) | luteinizing hormone beta polypeptide; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids | 0.576 |
GNAS | LHCGR | ENSP00000360141 | ENSP00000294954 | GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) | luteinizing hormone/choriogonadotropin receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | 0.969 |