Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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 | NHP2L1 | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (128 aa) | ||
 | EXOSC5 | exosome component 5; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The R [...] (235 aa) | ||
 | FBL | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (321 aa) | ||
 | DDX49 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 (483 aa) | ||
 | MPHOSPH6 | M-phase phosphoprotein 6; RNA-binding protein that associates with the RNA exosome complex. Involved in the 3’processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D (160 aa) | ||
 | NOP58 | NOP58 ribonucleoprotein homolog (yeast); Required for 60S ribosomal subunit biogenesis (By similarity) (529 aa) | ||
 | RPS27A | ribosomal protein S27a (156 aa) | ||
 | MKI67IP | MKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa) | ||
 | NOL6 | nucleolar protein family 6 (RNA-associated) (1146 aa) | ||
 | EXOSC4 | exosome component 4; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The R [...] (245 aa) | ||
 | RPS27L | ribosomal protein S27-like (84 aa) | ||
 | FCF1 | FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity) (198 aa) | ||
 | DDX47 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 47; Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors (455 aa) | ||
 | LTV1 | LTV1 homolog (S. cerevisiae) (475 aa) | ||
 | RPS27 | ribosomal protein S27 (84 aa) | ||
 | EXOSC2 | exosome component 2; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The R [...] (293 aa) | ||
 | EXOSC10 | exosome component 10; Putative catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] (885 aa) | ||
 | EXOSC9 | exosome component 9; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The R [...] (456 aa) | ||
 | RPP40 | ribonuclease P/MRP 40kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (363 aa) | ||
 | NOP56 | NOP56 ribonucleoprotein homolog (yeast); Involved in the early to middle stages of 60S ribosomal subunit biogenesis (594 aa) | ||
 | RPP30 | ribonuclease P/MRP 30kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (322 aa) | ||
 | RPS18 | ribosomal protein S18 (152 aa) | ||
 | SENP3 | SUMO1/sentrin/SMT3 specific peptidase 3; Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation stat [...] (574 aa) | ||
 | TBL3 | transducin (beta)-like 3 (808 aa) | ||
 | RSL1D1 | ribosomal L1 domain containing 1 (490 aa) | ||
 | RPS15 | ribosomal protein S15 (145 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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