Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | CPA2 | carboxypeptidase A2 (pancreatic) (419 aa) | ||
 | PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1; Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML [...] (163 aa) | ||
 | CELA3A | chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity (270 aa) | ||
 | PGA5 | pepsinogen 5, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa) | ||
 | PGA3 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa) | ||
 | CELA3B | chymotrypsin-like elastase family, member 3B; Efficient protease with alanine specificity but only little elastolytic activity (270 aa) | ||
 | CELA2A | chymotrypsin-like elastase family, member 2A; Acts upon elastin (269 aa) | ||
 | CELA2B | chymotrypsin-like elastase family, member 2B; Acts upon elastin (269 aa) | ||
 | CTRC | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity (268 aa) | ||
 | PGA4 | pepsinogen 4, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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