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HGFAC HGFAC VWCE VWCE HABP2 HABP2 TFPI TFPI OTOGL OTOGL CELA2A CELA2A GABRB2 GABRB2 CELA3A CELA3A GABRR2 GABRR2 GLRA1 GLRA1 GABRR1 GABRR1 GLRA3 GLRA3 CELA2B CELA2B GLRA2 GLRA2 CELA3B CELA3B GLRA4 GLRA4 GABRB3 GABRB3 CTRC CTRC CELSR3 CELSR3 GABRB1 GABRB1 CPA4 CPA4 LXN LXN F12 F12 SCUBE3 SCUBE3 TNRC6B TNRC6B SCUBE2 SCUBE2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CELSR3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation (3312 aa)
GLRA2glycine receptor, alpha 2; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) (452 aa)
CPA4carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway (421 aa)
TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor); Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (304 aa)
F12coagulation factor XII (Hageman factor); Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (615 aa)
LXNlatexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation (222 aa)
GLRA3glycine receptor, alpha 3; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) (464 aa)
GABRB2gamma-aminobutyric acid (GABA) A receptor, beta 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (512 aa)
SCUBE3signal peptide, CUB domain, EGF-like 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression (993 aa)
HABP2hyaluronan binding protein 2; Cleaves the alpha-chain at multiple sites and the beta- chain between ’Lys-53’ and ’Lys-54’ but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII (560 aa)
CELA3Achymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity (270 aa)
GABRB1gamma-aminobutyric acid (GABA) A receptor, beta 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (474 aa)
GABRB3gamma-aminobutyric acid (GABA) A receptor, beta 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (473 aa)
VWCEvon Willebrand factor C and EGF domains; May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma (955 aa)
CELA3Bchymotrypsin-like elastase family, member 3B; Efficient protease with alanine specificity but only little elastolytic activity (270 aa)
CELA2Achymotrypsin-like elastase family, member 2A; Acts upon elastin (269 aa)
GLRA4glycine receptor, alpha 4; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) (417 aa)
CELA2Bchymotrypsin-like elastase family, member 2B; Acts upon elastin (269 aa)
CTRCchymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity (268 aa)
HGFACHGF activator; Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form (655 aa)
GABRR2gamma-aminobutyric acid (GABA) A receptor, rho 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission (490 aa)
OTOGLotogelin-like (2344 aa)
TNRC6Btrinucleotide repeat containing 6B; Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (1833 aa)
GLRA1glycine receptor, alpha 1; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) (457 aa)
GABRR1gamma-aminobutyric acid (GABA) A receptor, rho 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission (479 aa)
SCUBE2signal peptide, CUB domain, EGF-like 2 (971 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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