Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | CPA4 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway (421 aa) | ||
 | LXN | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation (222 aa) | ||
 | LBR | lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane (615 aa) | ||
 | CELA3A | chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity (270 aa) | ||
 | PGA5 | pepsinogen 5, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa) | ||
 | PGA3 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa) | ||
 | CELA3B | chymotrypsin-like elastase family, member 3B; Efficient protease with alanine specificity but only little elastolytic activity (270 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | CELA2A | chymotrypsin-like elastase family, member 2A; Acts upon elastin (269 aa) | ||
 | CELA2B | chymotrypsin-like elastase family, member 2B; Acts upon elastin (269 aa) | ||
 | CTRC | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity (268 aa) | ||
 | PGA4 | pepsinogen 4, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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