node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEF1G | PLGRKT | ENSP00000331901 | ENSP00000223864 | eukaryotic translation elongation factor 1 gamma; Probably plays a role in anchoring the complex to other cellular components | plasminogen receptor, C-terminal lysine transmembrane protein; Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9 | 0.557 |
PLAT | PLAU | ENSP00000220809 | ENSP00000361850 | plasminogen activator, tissue | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | 0.620 |
PLAT | PLG | ENSP00000220809 | ENSP00000308938 | plasminogen activator, tissue | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.963 |
PLAU | PLAT | ENSP00000361850 | ENSP00000220809 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | plasminogen activator, tissue | 0.620 |
PLAU | PLAUR | ENSP00000361850 | ENSP00000339328 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | plasminogen activator, urokinase receptor | 0.999 |
PLAU | PLG | ENSP00000361850 | ENSP00000308938 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.962 |
PLAUR | PLAU | ENSP00000339328 | ENSP00000361850 | plasminogen activator, urokinase receptor | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | 0.999 |
PLAUR | PLG | ENSP00000339328 | ENSP00000308938 | plasminogen activator, urokinase receptor | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.961 |
PLG | PLAT | ENSP00000308938 | ENSP00000220809 | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | plasminogen activator, tissue | 0.963 |
PLG | PLAU | ENSP00000308938 | ENSP00000361850 | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | 0.962 |
PLG | PLAUR | ENSP00000308938 | ENSP00000339328 | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | plasminogen activator, urokinase receptor | 0.961 |
PLG | PLGRKT | ENSP00000308938 | ENSP00000223864 | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | plasminogen receptor, C-terminal lysine transmembrane protein; Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9 | 0.945 |
PLGRKT | EEF1G | ENSP00000223864 | ENSP00000331901 | plasminogen receptor, C-terminal lysine transmembrane protein; Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9 | eukaryotic translation elongation factor 1 gamma; Probably plays a role in anchoring the complex to other cellular components | 0.557 |
PLGRKT | PLG | ENSP00000223864 | ENSP00000308938 | plasminogen receptor, C-terminal lysine transmembrane protein; Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9 | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.945 |