node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNPY1 | DNAJC3 | ENSP00000317439 | ENSP00000365991 | canopy 1 homolog (zebrafish) | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | 0.664 |
CNPY2 | DNAJC3 | ENSP00000273308 | ENSP00000365991 | canopy 2 homolog (zebrafish); Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | 0.664 |
CNPY2 | PDIA6 | ENSP00000273308 | ENSP00000272227 | canopy 2 homolog (zebrafish); Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation | protein disulfide isomerase family A, member 6; May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin | 0.477 |
CNPY2 | UBC | ENSP00000273308 | ENSP00000344818 | canopy 2 homolog (zebrafish); Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation | ubiquitin C | 0.620 |
DNAJC3 | CNPY1 | ENSP00000365991 | ENSP00000317439 | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | canopy 1 homolog (zebrafish) | 0.664 |
DNAJC3 | CNPY2 | ENSP00000365991 | ENSP00000273308 | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | canopy 2 homolog (zebrafish); Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation | 0.664 |
DNAJC3 | HYOU1 | ENSP00000365991 | ENSP00000384144 | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding | 0.939 |
DNAJC3 | PDIA6 | ENSP00000365991 | ENSP00000272227 | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | protein disulfide isomerase family A, member 6; May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin | 0.915 |
DNAJC3 | TMEM4 | ENSP00000365991 | ENSP00000446743 | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | Uncharacterized protein | 0.664 |
DNAJC3 | UBC | ENSP00000365991 | ENSP00000344818 | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | ubiquitin C | 0.752 |
GUSB | NAGLU | ENSP00000302728 | ENSP00000225927 | glucuronidase, beta; Plays an important role in the degradation of dermatan and keratan sulfates | N-acetylglucosaminidase, alpha; Involved in the degradation of heparan sulfate | 0.935 |
GUSB | UBC | ENSP00000302728 | ENSP00000344818 | glucuronidase, beta; Plays an important role in the degradation of dermatan and keratan sulfates | ubiquitin C | 0.670 |
HGSNAT | NAGLU | ENSP00000368965 | ENSP00000225927 | heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non- reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase | N-acetylglucosaminidase, alpha; Involved in the degradation of heparan sulfate | 0.987 |
HYOU1 | DNAJC3 | ENSP00000384144 | ENSP00000365991 | hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | 0.939 |
HYOU1 | PDIA5 | ENSP00000384144 | ENSP00000323313 | hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding | protein disulfide isomerase family A, member 5 | 0.550 |
HYOU1 | PDIA6 | ENSP00000384144 | ENSP00000272227 | hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding | protein disulfide isomerase family A, member 6; May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin | 0.843 |
HYOU1 | UGGT1 | ENSP00000384144 | ENSP00000259253 | hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding | UDP-glucose glycoprotein glucosyltransferase 1; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation | 0.539 |
NAGLU | GUSB | ENSP00000225927 | ENSP00000302728 | N-acetylglucosaminidase, alpha; Involved in the degradation of heparan sulfate | glucuronidase, beta; Plays an important role in the degradation of dermatan and keratan sulfates | 0.935 |
NAGLU | HGSNAT | ENSP00000225927 | ENSP00000368965 | N-acetylglucosaminidase, alpha; Involved in the degradation of heparan sulfate | heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non- reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase | 0.987 |
NAGLU | UBC | ENSP00000225927 | ENSP00000344818 | N-acetylglucosaminidase, alpha; Involved in the degradation of heparan sulfate | ubiquitin C | 0.620 |