ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

ABI family, member 3 (NESH) binding protein

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

cytoplasmic FMR1 interacting protein 2; Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

eukaryotic translation initiation factor 3, subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...]

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

enabled homolog (Drosophila); Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity)

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

phenylalanyl-tRNA synthetase, alpha subunit

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

growth factor receptor-bound protein 10

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

growth factor receptor-bound protein 7

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

KIAA0408

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

LIM domain binding 3

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

p21 protein (Cdc42/Rac)-activated kinase 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby [...]

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

p21 protein (Cdc42/Rac)-activated kinase 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream [...]

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

PDZ and LIM domain 5; May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity)

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

PDZ and LIM domain 7 (enigma); May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity)

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1; Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity)

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

transmembrane protein 147

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

WAS protein family, member 2; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex

ABI family, member 3 (NESH) binding protein

ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility